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Open AccessRash caused by lurasidone in old chinese patient with bipolar disorder: case-based review
Rash is one of common adverse drug reaction and which have been reported in typical and atypical antipsychotics. Reports of lurasidone induced skin reactions are sparse. In this study, we report a case of rash...
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Article
Open AccessEpigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC
Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge ...
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Open AccessComparing the effects of argon plasma coagulation and interferon therapy in patients with vaginal intraepithelial neoplasia: a single-center retrospective study
This study aimed to evaluate the clinical efficacy and safety of argon plasma coagulation (APC) therapy and interferon therapy in patients with grade I and II vaginal intraepithelial neoplasia (VaIN).
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Open AccessPredictive factors and adalimumab efficacy in managing chronic recurrence Vogt-Koyanagi-Harada disease
This study explores prognostic factors influencing Vogt-Koyanagi-Harada (VKH) disease and observes the efficacy and safety of Adalimumab (ADA) in treating recurrence in Vogt-Koyanagi-Harada (VKH) patients.
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Article
Open AccessEEG decoding for effects of visual joint attention training on ASD patients with interpretable and lightweight convolutional neural network
Visual joint attention, the ability to track gaze and recognize intent, plays a key role in the development of social and language skills in health humans, which is performed abnormally hard in autism spectrum...
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Open AccessThe potential role of RNA sequencing in diagnosing unexplained insensitivity to conventional chemotherapy in pediatric patients with B-cell acute lymphoblastic leukemia
Pediatric B-cell acute lymphoblastic leukemia (B-ALL) is a highly heterogeneous disease. According to large-scale RNA sequencing (RNA-seq) data, B-ALL patients can be divided into more than 10 subgroups. Howev...
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Open AccessDisruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial cells. Dysfunction of the pulmonary endothelial barrier plays a crucial role in the acute lung injury (ALI) and acute re...
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Article
Open AccessMetabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm
In our prior investigation, we discerned loss-of-function variants within the gene encoding glutamine-rich protein 2 (QRICH2) in two consanguineous families, leading to various morphological abnormalities in s...
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Open AccessAssessing the clinical diagnostic value of anti-Müllerian hormone in polycystic ovarian syndrome and its correlation with clinical and metabolism indicators
This study investigated the association between Anti-Müllerian Hormone (AMH) and relevant metabolic parameters and assessed its predictive value in the clinical diagnosis of polycystic ovarian syndrome (PCOS).
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Open AccessSystematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection
To figure out how does SARS-CoV-2 affect sperm parameters and what influencing factors affect the recovery of sperm quality after infection? We conducted a prospective cohort study and initially included 122 m...
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Open AccessSenescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice
Endplate sclerosis is a notable aspect of spine degeneration or aging, but the mechanisms remain unclear. Here, we report that senescent macrophages accumulate in the sclerotic endplates of lumbar spine instab...
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Open AccessApplication of DNA barcodes in the genetic diversity of hard ticks (Acari: Ixodidae) in Kazakhstan
Forty-five tick species have been recorded in Kazakhstan. However, their genetic diversity and evolutionary relationships, particularly when compared to ticks in neighbouring countries, remain unclear. In the ...
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Open AccessMeta-analysis shows the impacts of ecological restoration on greenhouse gas emissions
International initiatives set ambitious targets for ecological restoration, which is considered a promising greenhouse gas mitigation strategy. Here, we conduct a meta-analysis to quantify the impacts of ecolo...
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Article
A large-scale field investigation revealing the distribution characteristics of arsenic in earthworm tissues
Arsenic characteristics in earthworms and soils across 47 sites in China were studied.
Earthworm tissues showed lower arseni...
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Open AccessPlaqueNet: deep learning enabled coronary artery plaque segmentation from coronary computed tomography angiography
Cardiovascular disease, primarily caused by atherosclerotic plaque formation, is a significant health concern. The early detection of these plaques is crucial for targeted therapies and reducing the risk of ca...
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Article
Open AccessAdult head and neck rhabdomyosarcoma: radiotherapy- based treatment, outcomes, and predictors of survival
Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations....
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Open AccessAuthor Correction: Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia
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Open AccessA meta-analysis of loneliness among left-behind children in China
Due to the long-term separation from their parents, the physical and mental health development of left-behind children is not optimal. Among many psychological problems, loneliness is the most significant. We ...
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Open AccessSeeing both sides: context-aware heterogeneous graph matching networks for extracting-related arguments
Our research focuses on extracting exchanged views from dialogical documents through argument pair extraction (APE). The objective of this process is to facilitate comprehension of complex argumentative discou...
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Open AccessImplementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance
There is substantial evidence to support the use of several methods for preventing deep-vein thrombosis (DVT) following intracerebral hemorrhage (ICH). However, the extent to which these measures are implement...
