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Article
Open AccessEffects of a rainwater harvesting system on the soil water, heat and growth of apricot in rain-fed orchards on the Loess Plateau
Rainwater is the main water source in arid and semiarid areas of the Loess Plateau, where rainfall is generally insufficient, ineffective and underutilized during the growing season. Thus, improving rainwater ...
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Article
Spatial and temporal variations of precipitation in Northwest China during 1973-2019
The Shaanxi-Gansu-Ningxia (SGN) region in Northwest China has been challenged by drought and water shortage for decades. Based on the precipitation data from 30 weather stations in the SGN region during 1973–2...
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Article
Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway
Traumatic spinal cord injury (SCI) is a devastating condition with few efficacious drugs. Sinomenine, a bioactive alkaloid extracted from medicinal herb, has been used as a treatment of rheumatoid diseases. Th...
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Article
Heat of Boron Trifluoride–Methanol System Determined by Bunsen Ice Calorimeter
The complex heat of BF3 with methanol was measured by utilizing the principle of the Bunsen ice calorimeter. The complex heat of BF3–methanol was found to be 49.2 and 58.1 kJ/mol when the molar ratio of BF3 to me...
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Article
Open AccessVemurafenib in Chinese patients with BRAFV600 mutation–positive unresectable or metastatic melanoma: an open-label, multicenter phase I study
Melanoma is a rare, deadly disease without effective treatment options in China. Vemurafenib is a selective inhibitor of oncogenic BRAFV600 kinase approved in more than 90 countries, based on results obtained pri...
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Article
Open AccessLINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p
The roles of long non-coding RNAs (lncRNAs), a class of long non-protein-coding RNAs, in the tumorigenesis of ovarian epithelial cells remain unknown. In this study, we discovered that the expression of long inte...
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Article
Clinical Pharmacokinetics of Vemurafenib
Vemurafenib is an orally administered small-molecule inhibitor of the oncogenic BRAF kinase that is indicated for the treatment of patients with unresectable or metastatic melanoma harbouring BRAF ...
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Article
Open AccessPreparation and characterization of 10B boric acid with high purity for nuclear industry
Boric acid is often added into coolant as neutron capture agent for pressurized water reactor, whose amount is influenced by its abundance and purity. Therefore, the preparation of enriched 10B boric acid with hi...
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Article
First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors
BRAF mutations are a validated target for cancer therapy. A second-generation BRAF inhibitor with an improved preclinical safety profile (RG7256) was evaluated in a first-in-man study ...
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Article
Age-Dependent Pharmacokinetics of Lansoprazole in Neonates and Infants
Background: Evidence suggests that age may affect the pharmacokinetics of lansoprazole in pediatric patients, but little information is available in neonates and infants.
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Article
Kinetics of esterification of 2-keto-L-gulonic acid with methanol catalyzed by cation exchange resin
The kinetics of esterification of 2-keto-L-gulonic acid with methanol in the liquid phase catalyzed by cation exchange resin, D001, was studied. The experiments were carried out in a stirred batch reactor at 3...
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Article
Solvability for nonlinear elliptic equation with boundary perturbation
The solvability of nonlinear elliptic equation with boundary perturbation is considered. The perturbed solution of original problem is obtained and the uniformly valid expansion of solution is proved.
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Article
Canard Phenomena in Oscillations of a Surface Oxidation Reaction
In this paper we investigate canard phenomena occurring in oscillations of a surface oxidation reaction which can be modeled by a three-dimensional singularly perturbed system of ordinary differential equation...
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Article
Singular Homoclinic Bifurcations in a Planar Fast-Slow System
In this paper, a planar fast-slow system is considered. The existence of homoclinic orbits to a hyperbolic saddle or a saddle-node are proved by the rigorous mathematical analysis and geometric singular pertur...
