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  1. Article

    Open Access

    Transcriptional activation of USP16 gene expression by NFκB signaling

    Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlying

    Shou Yang, Juelu Wang, Shipeng Guo, Daochao Huang… in Molecular Brain (2019)

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  2. No Access

    Article

    Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer’s Disease in a Murine Model

    A majority of Alzheimer’s disease (AD) cases are sporadic without known cause. People who suffered from traumatic brain injury (TBI) are more likely to develop neurodegeneration and cognitive impairments. Howe...

    Dandan Lou, Yao Du, Daochao Huang, Fang Cai, Yun Zhang, Tinyu Li… in Molecular Neurobiology (2018)

  3. No Access

    Article

    Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes

    The majority of Alzheimer’s disease (AD) cases are sporadic with unknown causes. Many dietary factors including excessive alcohol intake have been reported to increase the risk to develop AD. The effect of alc...

    Daochao Huang, Mengjiao Yu, Shou Yang, Dandan Lou, Weitao Zhou… in Molecular Neurobiology (2018)

  4. No Access

    Article

    Regulation of SET Gene Expression by NFkB

    SET is elevated and mislocalized in the neuronal cytoplasm in brains of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Cytoplasm SET leads to inhibition of protein phosphatase 2A and is involved in ...

    Yi Feng, **aoyong Li, Weitao Zhou, Dandan Lou, Daochao Huang… in Molecular Neurobiology (2017)

  5. No Access

    Article

    Sp1 Regulates Human Huntingtin Gene Expression

    Huntington’s disease (HD) is a hereditary neurodegenerative disorder resulting from the expansion of a polyglutamine tract in the huntingtin protein. The expansion of cytosine–adenine–guanine repeats results i...

    Ruitao Wang, Yawen Luo, Philip T. T. Ly, Fang Cai… in Journal of Molecular Neuroscience (2012)

  6. Article

    Open Access

    Transcriptional Regulation of TMP21 by NFAT

    TMP21 is a member of the p24 cargo protein family, which is involved in protein transport between the Golgi apparatus and ER. Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to d...

    Shengchun Liu, Si Zhang, Kelley Bromley-Brits, Fang Cai… in Molecular Neurodegeneration (2011)

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    Article

    BACE1 Gene Promoter Single-Nucleotide Polymorphisms in Alzheimer’s Disease

    Alzheimer’s disease (AD) is the most neurodegenerative disorder leading to dementia. Neuritic plaque formation in brains is a hallmark of AD pathogenesis. Amyloid β protein (Aβ) is the central component of neu...

    Weihui Zhou, Fang Cai, Yu Li, George S. Yang… in Journal of Molecular Neuroscience (2010)