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Article
Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation
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Article
Open AccessTranscriptional activation of USP16 gene expression by NFκB signaling
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlying
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Article
Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer’s Disease in a Murine Model
A majority of Alzheimer’s disease (AD) cases are sporadic without known cause. People who suffered from traumatic brain injury (TBI) are more likely to develop neurodegeneration and cognitive impairments. Howe...
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Article
Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes
The majority of Alzheimer’s disease (AD) cases are sporadic with unknown causes. Many dietary factors including excessive alcohol intake have been reported to increase the risk to develop AD. The effect of alc...
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Article
Regulation of SET Gene Expression by NFkB
SET is elevated and mislocalized in the neuronal cytoplasm in brains of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Cytoplasm SET leads to inhibition of protein phosphatase 2A and is involved in ...
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Article
Sp1 Regulates Human Huntingtin Gene Expression
Huntington’s disease (HD) is a hereditary neurodegenerative disorder resulting from the expansion of a polyglutamine tract in the huntingtin protein. The expansion of cytosine–adenine–guanine repeats results i...
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Article
Open AccessTranscriptional Regulation of TMP21 by NFAT
TMP21 is a member of the p24 cargo protein family, which is involved in protein transport between the Golgi apparatus and ER. Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to d...
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Article
BACE1 Gene Promoter Single-Nucleotide Polymorphisms in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most neurodegenerative disorder leading to dementia. Neuritic plaque formation in brains is a hallmark of AD pathogenesis. Amyloid β protein (Aβ) is the central component of neu...