-
Article
Open AccessHeterogeneous changes in global glacial lakes under coupled climate warming and glacier thinning
Global glacial lakes have expanded markedly in recent decades, accompanied by many catastrophic glacial lake outburst floods. However, our understanding of glacial lake evolution and connections with global wa...
-
Article
Open AccessEnhanced glacial lake activity threatens numerous communities and infrastructure in the Third Pole
Glacial lake outburst floods (GLOFs) are among the most severe cryospheric hazards in the Third Pole, encompassing the Tibetan Plateau and surrounding Himalayas, Hindu Kush, and Tianshan Mountains. Recent stud...
-
Article
Open AccessGenetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis
Biofilm-related diseases are a group of diseases that tolerate antimicrobial chemotherapies and therefore are refractory to treatment. Periodontitis, a non-device chronic biofilm disease induced by dental plaq...
-
Article
Open AccessTemporal induction of Lhx8 by optogenetic control system for efficient bone regeneration
The spatiotemporal regulation of essential genes is crucial for controlling the growth and differentiation of cells in a precise manner during regeneration. Recently, optogenetics was considered as a potent te...
-
Article
Open AccessControl of mesenchymal stem cell biology by histone modifications
Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...
-
Article
Open AccessTooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral bi...
-
Article
Open AccessPLGA-based control release of Noggin blocks the premature fusion of cranial sutures caused by retinoic acid
Craniosynostosis (CS), the premature and pathological fusion of cranial sutures, is a relatively common developmental disorder. Elucidation of the pathways involved and thus therapeutically targeting it would ...
