5 Result(s)
within
WeiWen Chen
Cancer Research
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Article
Open AccessTargeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
Castration-resistant prostate cancer (CRPC) is currently the main challenge for prostate cancer (PCa) treatment, and there is an urgent need to find novel therapeutic targets and drugs. Prohibitin (PHB1) is a ...
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Article
Open AccessPPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2
The development of castration-resistant prostate cancer (CRPC) remains a major obstacle in the treatment of prostate cancer (PCa). Dysregulated mitochondrial function has been linked to the initiation and prog...
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Article
Open AccessBTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1
Cancer stem-like traits contribute to prostate cancer (PCa) progression and metastasis. Deciphering the novel molecular mechanisms underlying stem-like traits may provide important insight for develo** novel...
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Article
Open AccessTranscription factor CCAAT/enhancer binding protein alpha up-regulates microRNA let-7a-1 in lung cancer cells by direct binding
The transcription factor CCAAT/enhancer binding protein α (C/EBPα) and microRNA (miRNA) let-7a-1 act as tumor suppressors in many types of cancers including lung cancer. In the present study, we aim to investi...
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Article
The clinicopathological significance and potential drug target of E-cadherin in NSCLC
Human epithelial cadherin (E-cadherin), a member of transmembrane glycoprotein family, encoded by the E-cadherin gene, plays a key role in cell-cell adhesion, adherent junction in normal epithelial tissues, contr...
