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Article
Open AccessReciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activat...
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Article
Open AccessIntegrated bioinformatics analysis for exploring potential biomarkers related to Parkinson’s disease progression
Parkinson’s disease (PD) is a progressive neurodegenerative disease with increasing prevalence. Effective diagnostic markers and therapeutic methods are still lacking. Exploring key molecular markers and mecha...
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Article
Open AccessSubslab ultra low velocity anomaly uncovered by and facilitating the largest deep earthquake
It is enigmatic that M8+ earthquakes can take place at depth greater than 600 km inside the slab, where the P-T conditions generally do not favor seismic slip rate (~m/s) on faults. Here we provide fresh insig...
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Article
Bioinformatics Analysis and Experimental Validation for Exploring Key Molecular Markers for Glioblastoma
Glioblastoma (GBM) is the most common primary intracranial malignancy with a very low survival rate. Exploring key molecular markers for GBM can help with early diagnosis, prognostic prediction, and recurrence...
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Chapter and Conference Paper
Data Augmentation Method Based on Partial Noise Diffusion Strategy for One-Class Defect Detection Task
One-class defect detection has proven to be an effective technique. However, the performance of complex models is often limited by existing data augmentation methods. To address this issue, this paper proposes...
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Chapter and Conference Paper
Pothole-YOLO: A Single-Stage Instance Segmentation Method for Pothole Detection
Potholes pose a significant hazard to traffic safety and transportation infrastructure. Traditional methods of human-based pothole detection present challenges in terms of cost and safety. However, instance se...
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Article
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia
The Proteolipid Protein 2 (PLP2), a protein in the Endoplasmic Reticulum (ER) membrane, has been reported to be highly expressed in various tumors. Previous studies have demonstrated that the reduced PLP2 can ...
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Article
Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression
Phosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to abnormal activation of PI3K/AKT pathway. However, results from...
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Article
Effects of Dietary Supplementation with Lactobacillus acidophilus and Bacillus subtilis on Mucosal Immunity and Intestinal Barrier Are Associated with Its Modulation of Gut Metabolites and Microbiota in Late-Phase Laying Hens
We investigated the effects of dietary supplementation with Lactobacillus acidophilus and Bacillus subtilis on the intestinal immune response, intestinal barrier function, cecal microbiota profile, and metabolite...
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Article
Open AccessTargeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
Castration-resistant prostate cancer (CRPC) is currently the main challenge for prostate cancer (PCa) treatment, and there is an urgent need to find novel therapeutic targets and drugs. Prohibitin (PHB1) is a ...
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Article
Open AccessChanges in sucrose metabolism patterns affect the early maturation of Cassava sexual tetraploid roots
Cassava (Manihot esculenta Crantz) is an important multiuse crop grown for economic and energy purposes. Its vegetative organs are storage roots, in which the main storage material is starch. The accumulation cha...
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Article
Effect of scanning mode on temperature field and interface morphology of laser joining between CFRTP and TC4 titanium alloy
Dissimilar components composed of CFRTP (Carbon Fiber Reinforced Thermoplastic Polymer) and TC4 titanium alloy are increasingly applied in the aerospace field. The scanning mode offers a significant influence ...
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Article
Open AccessPPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2
The development of castration-resistant prostate cancer (CRPC) remains a major obstacle in the treatment of prostate cancer (PCa). Dysregulated mitochondrial function has been linked to the initiation and prog...
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Article
Identification and functional characterization of three iridoid synthases in Gardenia jasminoides
The discovery of three iridoid synthases (GjISY, GjISY2 and GjISY4) from Gardenia jasminoides and their functional characterization increase the understanding of iridoid scaffold/iridoid glycoside biosynthesis in...
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Article
Open AccessNovel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway
NF-κB signaling pathway is a critical link between inflammation and cancer. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were involved in dysregulation of NF-κB. Herein, we reported a novel ...
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Chapter and Conference Paper
User Experience Design Method from the Perspective of Scalability
The era that focused on material aspects such as production and function has already passed. Modern design values spiritual aspects such as thoughts and feelings. Facing the increasingly lengthy and complex dy...
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Chapter and Conference Paper
Research on the Influence Factors of Designer’s Emotion in the Design Process
The emotional change of a designer may lead to a different design decision and therefore affect the outcome of the design. This paper aims to explore factors that affect the emotions of designers during the de...
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Article
Roux-en-Y gastric bypass and gastric sleeve surgery result in long term bone loss
Little is known about the long-term skeletal impact of bariatric procedures, particularly the increasingly commonly performed gastric sleeve surgery (GS). We examined bone density (BMD) change following three ...
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Article
FoxO directly regulates the expression of TOR/S6K and vitellogenin to modulate the fecundity of the brown planthopper
As a conserved transcription factor, FoxO plays a crucial role in multiple physiological processes in vivo, including stress resistance, longevity, growth and reproduction. Previous studies on FoxO have focused o...
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Chapter and Conference Paper
Toward a Theory-Driven Model of Emotional Interaction Design in Mobile Games Research
The rapid development of mobile information technology provides good opportunities for the maturity and growth of mobile games. In busy modern life, mobile games are playing an increasingly important role in p...
