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Article
A new gold(I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis. It is frequently overexpressed in various cancer cells, including prostate cancer, making it a promising target for the development of ...
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Article
Open AccessRab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
Stomach adenocarcinoma (STAD) is one of the leading causes of cancer-related death globally. Metastasis and drug resistance are two major causes of failures in current chemotherapy. Here, we found that the exp...
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Article
Open AccessArgonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos
In mammalian early embryos, the transition from maternal to embryonic control of gene expression requires timely degradation of a subset of maternal mRNAs (MRD). Recently, zygotic genome activation (ZGA)-depen...
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Article
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interaction...
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Article
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...
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Article
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice. ...