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Article
Open AccessMannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...
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Article
Open AccessRab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
Stomach adenocarcinoma (STAD) is one of the leading causes of cancer-related death globally. Metastasis and drug resistance are two major causes of failures in current chemotherapy. Here, we found that the exp...
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Article
Open AccessClinical and genomic features in patients with second primary glioblastoma following first primary renal cell carcinoma
To explore the potential pathogenesis and clinical features of second primary glioblastoma (spGBM) following first primary renal cell carcinoma (fpRCC).
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Article
Open AccessHK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) i...
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Article
Open AccessMachine learning-based Radiomics analysis for differentiation degree and lymphatic node metastasis of extrahepatic cholangiocarcinoma
Radiomics may provide more objective and accurate predictions for extrahepatic cholangiocarcinoma (ECC). In this study, we developed radiomics models based on magnetic resonance imaging (MRI) and machine learn...
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Article
Open AccessThe metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (...
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Article
Open AccessArgonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos
In mammalian early embryos, the transition from maternal to embryonic control of gene expression requires timely degradation of a subset of maternal mRNAs (MRD). Recently, zygotic genome activation (ZGA)-depen...
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Article
HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells
Long non-coding RNAs (LncRNAs) exert their functions mainly by binding to their corresponding proteins. Runt-related transcription factor 3 (Runx3) is an important transcription factor that functions as a tumo...
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Article
Open AccessNur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates g...
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Article
Open AccessMalaria from hyperendemicity to elimination in Hekou County on China–Vietnam border: an ecological study
Malaria control and elimination are challenged by diversity and complexity of the determinants on the international border in the Great Mekong Sub-region. Hekou, a Chinese county on the China–Vietnam border, w...
