53 Result(s)
within
Wei Fan
Life Sciences
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Article
Open AccessA feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated ...
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Mechanisms of Triton X-100 reducing the Ag+-resistance of Enterococcus faecalis
To investigate the mechanism of Triton X-100 (TX-100) reducing the Ag+-resistance of Enterococcus faecalis (E. faecalis), and evaluate the antibacterial effect of TX-100 + Ag+ against the induced Ag+-resistant E....
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Open AccessRNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of cellular metabolism, glycolysis provides energy and biomolecules important fo...
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Open AccessIntegrated metabolome and transcriptome analyses reveal the molecular mechanism underlying dynamic metabolic processes during taproot development of Panax notoginseng
Panax notoginseng (Burk) F. H. Chen is one of the most famous Chinese traditional medicinal plants. The taproot is the main organ producing triterpenoid saponins, and its development is directly linked to the qua...
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Open AccessAuthor Correction: The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence
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Open AccessSoil bacterial and fungal communities resilience to long-term nitrogen addition in subtropical forests in China
Atmospheric nitrogen (N) deposition is predicted to increase, especially in the subtropics. However, the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical fo...
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Bidirectional two-sample mendelian randomization analysis identifies causal associations between age at menarche and sarcopenia-related traits
Observational studies have shown that the age of menarche is associated with sarcopenia, but confounding factors make the causal relationship difficult to infer.
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Open AccessInhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase
Extranodal NK/T-cell lymphoma (NKTL) is a rare and aggressive form of extranodal lymphoma with a poor prognosis. Currently, there are very limited treatment options for patients with advanced-stage disease or ...
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Open AccessYY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2
Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactyla...
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Effects of intercrop** systems of Phyllostachys edulis and Bletilla striata on soil bacterial community composition and function
Intercrop** can result in changes in vegetation and soil properties, which could affect soil bacterial communities and functions that play critically important roles in the biogeochemical cycles in terrestri...
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Open AccessChromosome-level genome of black cutworm provides novel insights into polyphagy and seasonal migration in insects
The black cutworm, Agrotis ipsilon, is a serious global underground pest. Its distinct phenotypic traits, especially its polyphagy and ability to migrate long distances, contribute to its widening distribution an...
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Open AccessFusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis
Z-DNA binding protein 1 (ZBP1) is a vital innate immune sensor that regulates inflammation during pathogen invasion. ZBP1 may contribute to pyroptosis, apoptosis and necroptosis in infectious diseases. In this...
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Open AccessEndHiC: assemble large contigs into chromosome-level scaffolds using the Hi-C links from contig ends
The application of PacBio HiFi and ultra-long ONT reads have enabled huge progress in the contig-level assembly, but it is still challenging to assemble large contigs into chromosomes with available Hi-C scaff...
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Ectopic Expression of Erigeron breviscapus JAZ1 Affects JA-Induced Development Processes in Transgenic Arabidopsis
The jasmonate ZIM-domain (JAZ) proteins are repressors that function in the regulation of plant growth, development, and response to stimulation of different signals in the JA signaling pathway. Erigeron brevisca...
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Open AccessGene fusion as an important mechanism to generate new genes in the genus Oryza
Events of gene fusion have been reported in several organisms. However, the general role of gene fusion as part of new gene origination remains unknown.
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AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids
Phospholipid levels are influenced by peripheral metabolism. Within the central nervous system, synaptic phospholipids regulate glutamatergic transmission and cortical excitability. Whether changes in peripher...
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Open AccessThe flying spider-monkey tree fern genome provides insights into fern evolution and arborescence
To date, little is known about the evolution of fern genomes, with only two small genomes published from the heterosporous Salviniales. Here we assembled the genome of Alsophila spinulosa, known as the flying spi...
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Open AccessChemically defined and small molecules-based generation of sinoatrial node-like cells
Existing methods for in vitro differentiation of human pluripotent stem cells (hPSCs) into sinoatrial node-like cells (SANLCs) require complex and undefined medium constituents. This might hinder the elucidati...
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Enhanced antibacterial effect against Enterococcus faecalis by silver ions plus Triton X-100 with low concentrations and cytotoxicity
Enterococcus faecalis (E. faecalis) is commonly considered to be one of chief culprits of secondary and persistent root canal infections. As antibiotic resistance has become a global issue, in order to reduce the...
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Transcriptome Analysis Reveals Molecular Mechanisms Underlying Methyl Jasmonate-mediated Biosynthesis of Protopanaxadiol-type Saponins in Panax notoginseng Leaves
Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly u...
