252 Result(s)
within
Wei**g Hu
Biomedicine
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Article
Open AccessProtopanaxadiols Eliminate Behavioral Impairments and Mitochondrial Dysfunction in Parkinson’s Disease Mice Model
Currently, there are no effective therapies to cure Parkinson’s disease (PD), which is the second most common neurodegenerative disease primarily characterized by motor dysfunction and degeneration of dopamine...
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with exp...
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Open AccessLong-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma
Nasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes. High-dose radiotherapy is a key treatment for patients with NACC. This ...
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Increased FGL1 Expression Predicts Poor Prognosis and Promotes EMT in Head and Neck Squamous Cell Carcinoma
Fibrinogen-like protein 1 (FGL1) is a proliferation- and metabolism-related factor secreted by the liver that is aberrantly expressed and functionally abnormal in human malignancies. However, the role of FGL1 in ...
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Inter-fractional portability of deep learning models for lung target tracking on cine imaging acquired in MRI-guided radiotherapy
MRI-guided radiotherapy systems enable beam gating by tracking the target on planar, two-dimensional cine images acquired during treatment. This study aims to evaluate how deep-learning (DL) models for target ...
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Open AccessHigh-frame-rate contrast-enhanced ultrasound to differentiate between clear cell renal cell carcinoma and angiomyolipoma
To investigate the diagnostic efficacy of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in differentiating between clear cell renal cell carcinoma (CCRCC) and angiomyolipoma (AML).
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Open AccessCharacterizing genetic variation on the Z chromosome in Schistosoma japonicum reveals host-parasite co-evolution
Schistosomiasis is a neglected tropical disease that afflicts millions of people worldwide; it is caused by Schistosoma, the only dioecious flukes with ZW systems. Schistosoma japonicum is endemic to Asia; the Z ...
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Open AccessStress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
Hepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechani...
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Open AccessAge at lung cancer diagnosis in females versus males who never smoke by race and ethnicity
We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
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Article
miR-29b-3p Affects the Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis and its Mechanism
To explore the effect of miR-29b-3p on fibrosis and hypertrophy of ligamentum flavum (LF) in lumbar spinal stenosis (LSS) and its underlying mechanism. Patients with LSS and lumbar disc herniation (LDH) (contr...
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Open AccessCorrection: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer
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Article
Publisher Correction: The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+T cell fates
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Article
The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease
The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular localization of Rho-associated kinase (ROCK), which r...
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Open AccessAssociation between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort study and Mendelian randomization. The dataset contained a subst...
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Open AccessAURKB promotes bladder cancer progression by deregulating the p53 DNA damage response pathway via MAD2L2
Bladder cancer (BC) is the most common urinary tract malignancy. Aurora kinase B (AURKB), a component of the chromosomal passenger protein complex, affects chromosomal segregation during cell division. Mitotic...
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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk
Previous studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS), including rs17824933 in the CD6 gene, rs1883832 in the CD40 gene, rs23...
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Open AccessIdentification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate
Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) ...
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Article
Open AccessAn improved medium for in vitro studies of female reproduction and oviposition in Schistosoma japonicum
Schistosomiasis is a disease primarily caused by eggs laid by pathogens called schistosomes. Among the schistosome species infecting humans, Schistosoma japonicum possesses the largest fecundity; each adult femal...
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Article
The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates
Antigen-experienced CD8+ T cells form effector and central memory T cells (TEM and TCM cells, respectively); however, the mechanism(s) controlling their lineage plasticity remains incompletely understood. Here we...
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Article
Comparison of pharmacokinetics and safety of albuvirtide in healthy subjects after intravenous drip and bolus injection
Albuvirtide (ABT) is the first long-acting HIV fusion inhibitor developed in China, blocking the invasion of HIV-1 virus into target cells. This study aimed to compare the pharmacokinetics (PK), tolerability, ...
