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2,155 Result(s)
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Open AccessIdentification of a novel lactylation-related gene signature predicts the prognosis of multiple myeloma and experiment verification
Multiple myeloma (MM) is an incurable hematological malignancy with poor survival. Accumulating evidence reveals that lactylation modification plays a vital role in tumorigenesis. However, research on lactylat...
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Design and optimization of carbon materials as anodes for advanced potassium-ion storage
With the swift advancement of renewable energy and escalating demands for energy storage, potassium-ion batteries (PIBs) are increasingly recognized as a potent energy storage technology. Various carbon anode ...
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Gold nanoparticle-decorated fluorine-doped tin oxide substrate for sensitive label-free OIRD microarray chips
Oblique incidence reflectance difference (OIRD) is an emerging technique enabling real-time and label-free detection of bio-affinity binding events on microarrays. The interfacial architecture of the microarra...
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Open AccessProtopanaxadiols Eliminate Behavioral Impairments and Mitochondrial Dysfunction in Parkinson’s Disease Mice Model
Currently, there are no effective therapies to cure Parkinson’s disease (PD), which is the second most common neurodegenerative disease primarily characterized by motor dysfunction and degeneration of dopamine...
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Open AccessSystem-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning
The suprachiasmatic nucleus (SCN) is the mammalian central circadian pacemaker with heterogeneous neurons acting in concert while each neuron harbors a self-sustained molecular clockwork. Nevertheless, how sys...
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with exp...
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Multi-omics Study of Hypoxic-Ischemic Brain Injury After Cardiopulmonary Resuscitation in Swine
Hypoxic-ischemic brain injury is a common cause of mortality after cardiac arrest (CA) and cardiopulmonary resuscitation; however, the specific underlying mechanisms are unclear. This study aimed to explore po...
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Flexible Bayesian quantile regression based on the generalized asymmetric Huberised-type distribution
To enhance the robustness and flexibility of Bayesian quantile regression models using the asymmetric Laplace or asymmetric Huberised-type (AH) distribution, which lacks changeable mode, diminishing influence ...
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Open AccessObservation of topologically enhanced third harmonic generation in doubly resonant nonlinear topolectrical circuits
The ability to confine and guide wave makes topological physics a promising platform for large local field enhancement and strong scattering immunity, which enables efficient nonlinear processes. In this resea...
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Correction to: Functional analysis of MeCIPK23 and MeCBL1/9 in cassava defense response against Xanthomonas axonopodis pv. Manihotis
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Open AccessFull-length transcriptome sequencing of Arabidopsis plants provided new insights into the autophagic regulation of photosynthesis
Autophagy is a highly conserved eukaryotic pathway and plays a crucial role in cell survival under stress conditions. Here, we applied a full-length transcriptome approach to study an Arabidopsis autophagy mutant...
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Open AccessIntangible cultural heritage research in China from the perspective of intellectual property rights based on bibliometrics and knowledge map**
This research scrutinizes the trends and dynamics of Intellectual Property Protection (IPP) of Intangible Cultural Heritage (ICH) in China, utilizing a dataset of 91 papers from the CNKI database spanning 2011...
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Open AccessIntegrating Iso-seq and RNA-seq data for the reannotation of the greater amberjack genome
The greater amberjack is a very important fishery species with high commercial value, and it is distributed worldwide. Transcriptome-based studies on S. dumerili have been limited by an inadequate reference genom...
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Open AccessDevelopment of an HSV-1 production process involving serum-reduced culturing and bead-to-bead transfer
Herpes simplex virus type 1 (HSV-1) plays an important role in the field of gene therapy and viral vaccines, especially as an oncolytic virus. However, the mass production of HSV-1 viral vectors remains a chal...
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Open AccessLong-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma
Nasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes. High-dose radiotherapy is a key treatment for patients with NACC. This ...
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Open AccessA comparative analysis of sivelestat sodium hydrate and ulinastatin combination therapy in the treatment of sepsis with acute respiratory distress syndrome
This comparative analysis aimed to investigate the efficacy of Sivelestat Sodium Hydrate (SSH) combined with Ulinastatin (UTI) in the treatment of sepsis with acute respiratory distress syndrome (ARDS).
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An improved density peaks clustering algorithm using similarity assignment strategy with K-nearest neighbors
Some particular shaped datasets, such as manifold datasets, have restrictions on density peak clustering (DPC) performance. The main reason of variations in sample densities between clusters of data and uneven...
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Open AccessA cytosol-tethered YHB variant of phytochrome B retains photomorphogenic signaling activity
The red and far-red light photoreceptor phytochrome B (phyB) transmits light signals following cytosol-to-nuclear translocation to regulate transcriptional networks therein. This necessitates changes in protei...
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GDPS: an open-source python-based software package for multi-GNSS data preprocessing
Global Navigation Satellite System (GNSS) data preprocessing is crucial for achieving high-precision navigation, positioning, and timing applications to convert the data format, edit the data content, and anal...
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Comment on: “Prognostic and Predictive Value of PIK3CA Mutations in Metastatic Colorectal Cancer”