14 Result(s)

Article

OliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets

The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleot...

Zhi-Xue Yang, Dong-Hao Deng, Zhu-Ying Gao, Zhi-Kang Zhang… in Communications Biology (2024)

Article

Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation

Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2 inflammation. However, the underlying mechanism remains uncertai...

**umin Chen, Changhui Chen, Zhaoxu Tu, Zeling Guo, Tong Lu, Jian Li… in Cell Death Discovery (2024)

Article

Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing

CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur...

Juan-Juan Zhao, **n-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin… in BMC Genomics (2024)

Article

Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors

Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies have many challenges due to its inconsistent potency and limited quantity. Here, we report a strategy to generate induced ...

Wanqiu Chen, Chenguang Wang, Zhi-Xue Yang, Feng Zhang, Wei Wen… in Communications Biology (2023)

Article

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling

Chromodomain helicase DNA binding protein (CHD) family plays critical roles in regulating gene transcription. The family is linked to cancer disease, but the family member’s role in tumorigenesis remains largely ...

Boyu Zhang, Qingxin Liu, Weijie Wen, Han Gao, Wenxia Wei, Aiwen Tang… in Cell Discovery (2022)

Article

Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA inte...

Wei Wen Teo, **nang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou… in Communications Biology (2022)

Article

Correction to: Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt

Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed… in BMC Genomics (2022)

Article

Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt

Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology and transmission mechanisms of CR-hvKP and the correspondin...

Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed… in BMC Genomics (2022)

Article

Loss of TACC1 variant25 inducing cell proliferation and suppressing autophagy in head and neck squamous carcinoma

Transforming acidic coiled-coil containing protein1 (TACC1) is closely related to transcription, translation and centrosome dynamics. Dysregulation of TACC1 is associated with multiple malignancies. Alternativ...

Pan Xu, Ran Zhao, Chen-Yang Zhang, Qian-Qian Zhang, Yong Wang… in Cell Death Discovery (2021)

Article

Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yang **a, Ke Wei, Feng-Ming Yang, Liu-Qing Hu, Chun-Feng Pan… in Cell Death & Disease (2020)

Article

miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC

Non-small cell lung cancer (NSCLC) is one of the most common aggressive malignancies. miRNAs have been identified as important biomarkers and regulators of NSCLC. However, the functional contributions of miR-1...

Yang **a, Ke Wei, Feng-Ming Yang, Liu-Qing Hu, Chun-Feng Pan… in Cell Death & Disease (2019)

Article

p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure

Hypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause ...

Chih-Yang Huang, Pei-Ying Pai, Chia-Hua Kuo, Tsung-Jung Ho… in Cell Death & Disease (2017)

Article

Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Doxorubicin (DOX) is one of the most effective antitumor drugs, but its cardiotoxicity has been a major concern for its use in cancer therapy for decades. Although DOX-induced cardiotoxicity has been investiga...

Chih-Yang Huang, Wei-Wen Kuo, Jeng-Fan Lo, Tsung-Jung Ho… in Cell Death & Disease (2016)

Article

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy

Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes. Canonical autophagy requires all autophagy proteins (ATGs), whereas non...

Ying Gao, Yajun Liu, Liang Hong, Zuolong Yang, **nran Cai… in Cell Death & Disease (2016)