35 Result(s)
within
W. E. Müller
English
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Article
1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer’s disease (AD) are not fully understood. However, alterations of glucose metabolism and mitochondrial dysfunction certainly play...
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Article
Efficacy of St. John’s wort extract WS® 5570 in acute treatment of mild depression
Based on the original data from two double-blind, randomized, placebo-controlled clinical trials and the acute phase of a long-term study that investigated the antidepressant efficacy of St. John’s wort extrac...
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Chapter and Conference Paper
Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. The AD...
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Reference Work Entry In depth
Cholesterol—A Janus-Faced Molecule in the Central Nervous System
Understanding the role of cholesterol in normal brain function and its involvement in specific neurodegenerative diseases has attracted considerable attention. One general observation is that there are notable...
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Article
Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer’s disease
The presumption to suffer from Alzheimer’s disease (AD) accelerates with aging. One important risk factor seems to be the isoform epsilon 4 of the apolipoprotein E gene (Apo ɛ4), which increases the risk to de...
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Article
Statins: drugs for Alzheimer’s disease?
Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer’s disease (AD). This relationship is supported by retrospective epidemiological studies demons...
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Chapter
Membrane Disordering Effects of β-Amyloid Peptides
The interaction of Aβ with synaptosomal plasma membranes decreases membrane fluidity. Using model membrane/Iiposome systems the interaction of Aβ with specific lipids (e.g. phospholipids, gangliosides, cholestero...
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Article
Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brain
Since oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease (AD) and since the age-adjusted incidence of AD is higher in females than males, we examined a possible influence of ge...
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Chapter
Symposia
Goal: The goal of this symposium is to identify ‘state-of-the-art’ strategies for the use of antipsychotic medications in the management of children and adolescents with major psychiatric disorders. Learning o...
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Article
Specific modulation of sigma binding sites by the anxiolytic drug opipramol
The atypical anxiolytic and antidepressive drug opipramol binds with high affinity to σ1 and somewhat lower affinity to σ2 sites. After subchronic treatment, opipramol significantly down-regulated σ2 but not σ1 ...
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Article
Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis...
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Article
ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain
The objective of this study was to determine the specific relationship between brain aging and changes in the level of oxidative stress, lipid peroxidation (LPO) and in the activities of antioxidant enzymes. ...
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Article
Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes
The effects of aging and of different amyloid β-peptides (Aβ) on the properties of purified synaptosomal plasma and mitochondrial membranes were studied using different fluorescent dyes. Aging led to opposite...
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Chapter
Pharmacological and Nonpharmacological Approaches to the Treatment of Dementia
All approaches to the treatment of dementia are intended primarily to improve cognitive deficits and the factors responsible for them, and secondarily to improve the accompanying “noncognitive” manifestations....
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Article
Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to α1-receptor up-regulation
While many evidences indicate that deficits of central noradrenergic neurotransmission are involved in the age-related decline of cognitive functions in animals and man, very little is known about the specifi...
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Article
Piracetam reverses hippocampal membrane alterations in Alzheimer's disease
The in vitro effects of piracetam treatment on the fluidity of membranes from the hippocampus of Alzheimer's Disease patients (AD) and non-demented controls were studied. Hippocampal membranes of AD patients sho...
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Chapter and Conference Paper
Lymphocytes as cell model to study apoptosis in Alzheimer’s disease: vulnerability to programmed cell death appears to be altered
Recent evidence indicates that programmed cell death (apoptosis) may contribute to neuronal death in Alzheimer’s disease (AD). In situ data derived from post mortem brain tissue indicate that DNA fragmentation wh...
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Article
Learning abilities depend on NMDA-receptor density in hippocampus in adult rats
The hippocampal NMDA-receptor is predominantly involved to establish long-term potentation (LTP) which is assumed to underlie fundamental molecular mechanisms of learning and memory. In the present study, NMDA...
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Article
Abstracts Second Congress of the European Society for Clinical Neuropharmacology
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Chapter
Pharmacology of the GABAergic/Benzodiazepine System
Although γ-aminobutyric acid (GABA) was discovered only as recently as 1950, today we have convincing evidence that GABA represents the most important inhibitory neurotransmitter of the mammalian central nervo...
