52 Result(s)
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Article
1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer’s disease (AD) are not fully understood. However, alterations of glucose metabolism and mitochondrial dysfunction certainly play...
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Chapter
Störungen der Neurotransmission und Signaltransduktion als Grundlage psychischer Erkrankungen
Die Rolle von Neurotransmittersystemen in der Physiologie der Gehirnfunktionen ist ebenso unbestritten wie deren Beteiligung an pathologischen Veränderungen, die letztlich zu den Symptomen psychischer Krankhei...
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Chapter
Psychopharmakotherapie — Pharmakologische Grundlagen
Das Verständnis der pharmakologischen Grundlagen der Psychopharmakotherapie ermöglicht es zum einen, neue Forschungsansätze auf dem Gebiet der psychiatrischen Pharmakotherapie nachzuvollziehen. Für den klinisc...
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Article
Efficacy of St. John’s wort extract WS® 5570 in acute treatment of mild depression
Based on the original data from two double-blind, randomized, placebo-controlled clinical trials and the acute phase of a long-term study that investigated the antidepressant efficacy of St. John’s wort extrac...
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Article
Behandlung mit Methylphenidat im Kindesalter
Die Therapie der Aufmerksamkeitsdefizit-Hyperaktivitäts-Störung mit Stimulanzien gehört zu den am besten untersuchten medikamentösen Interventionen. Eine Behandlung mit Methylphenidat in Kombination mit psycho...
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Chapter and Conference Paper
Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. The AD...
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Article
Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer’s disease
The presumption to suffer from Alzheimer’s disease (AD) accelerates with aging. One important risk factor seems to be the isoform epsilon 4 of the apolipoprotein E gene (Apo ɛ4), which increases the risk to de...
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Article
Statins: drugs for Alzheimer’s disease?
Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer’s disease (AD). This relationship is supported by retrospective epidemiological studies demons...
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Chapter
Auswahl des Antidepressivums anhand pharmakologischer Wirkprofile
Die heutigen Möglichkeiten, auf der Basis der sehr unterschiedlichen pharmakologischen Eigenschaften der etwa 30 zurzeit in Deutschland zur Verfügung stehenden Antidepressiva eine möglichst relevante Auswahl e...
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Article
Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brain
Since oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease (AD) and since the age-adjusted incidence of AD is higher in females than males, we examined a possible influence of ge...
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Chapter
Symposia
Goal: The goal of this symposium is to identify ‘state-of-the-art’ strategies for the use of antipsychotic medications in the management of children and adolescents with major psychiatric disorders. Learning o...
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Article
Specific modulation of sigma binding sites by the anxiolytic drug opipramol
The atypical anxiolytic and antidepressive drug opipramol binds with high affinity to σ1 and somewhat lower affinity to σ2 sites. After subchronic treatment, opipramol significantly down-regulated σ2 but not σ1 ...
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Chapter
Psychopharmakotherapie: pharmakologische Grundlagen
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Chapter and Conference Paper
Auswahl eines Antidepressivums unter dem Aspekt des Qualitätsmanagements
Zur Therapie depressiver Erkrankungen stehen heute bei uns mehr als 20 Antidepressiva zur Verfügung, die über sehr unterschiedliche biochemische Wirkmechanismen letztlich sehr ähnliche antidepressive Effekte b...
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Article
Subakuter, einseitiger Visusverlust
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Chapter and Conference Paper
Neurotransmitter
Ausgangspunkt für die Entwicklung der heutigen Antidepressiva waren die Entdeckung der thymoleptischen Wirkung des trizyklischen Präparates Imipramin im Jahre 1957 und die Beobachtung des stimmungsaufhellenden...
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Article
Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis...
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Article
ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain
The objective of this study was to determine the specific relationship between brain aging and changes in the level of oxidative stress, lipid peroxidation (LPO) and in the activities of antioxidant enzymes. ...
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Article
Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes
The effects of aging and of different amyloid β-peptides (Aβ) on the properties of purified synaptosomal plasma and mitochondrial membranes were studied using different fluorescent dyes. Aging led to opposite...
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Chapter
Pharmacological and Nonpharmacological Approaches to the Treatment of Dementia
All approaches to the treatment of dementia are intended primarily to improve cognitive deficits and the factors responsible for them, and secondarily to improve the accompanying “noncognitive” manifestations....
