Skip to main content

8 Result(s)

within W T Beck Remove this filter

and

  1. Article

    Open Access

    Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties

    We have investigated some roles of splicing factor polypyrimidine tract-binding protein (PTBP1) in human breast cancer. We found that PTBP1 was upregulated in progressively transformed human mammary epithelial...

    X He, A D Arslan, T-T Ho, C Yuan, M R Stampfer, W T Beck in Oncogenesis (2014)

    Download PDF (1069 KB) View Article

  2. No Access

    Article

    Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer

    Our previous study revealed that two splicing factors, polypyrimidine tract-binding protein (PTB) and SRp20, were upregulated in epithelial ovarian cancer (EOC) and knockdown of PTB expression inhibited ovaria...

    X He, A D Arslan, M D Pool, T-T Ho, K M Darcy, J S Coon, W T Beck in Oncogene (2011)

  3. No Access

    Article

    Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro

    Polypyrimidine tract-binding protein (PTB) is an RNA-binding protein with multiple functions in the regulation of RNA processing and IRES-mediated translation. We report here overexpression of PTB in a majorit...

    X He, M Pool, K M Darcy, S B Lim, N Auersperg, J S Coon, W T Beck in Oncogene (2007)

  4. No Access

    Chapter and Conference Paper

    The Role of DNA Topoisomerase II in Multidrug Resistance in Human Leukemia

    Resistance to chemotherapy continues to be a major impediment and intellectual challenge to the cure of neoplastic diseases, and leukemias are no exception. Resistance of tumor cells to multiple “natural produ...

    W. T. Beck, T. Funabiki, M. K. Danks in Acute Leukemias (1992)

  5. No Access

    Article

    Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

    Bridget T. Hill, L. K. Hosking, S. McClean… in Journal of Cancer Research and Clinical On… (1991)

  6. No Access

    Chapter and Conference Paper

    Issues in multidrug resistance

    Tumor cell resistance to multiple « natural product » anticancer drugs, known as multidrug resistance (MDR), is now a well-documented phenomenon, and some excellent reviews have recently summarized its pharmac...

    W. T. Beck, M. K. Danks, T. Funabiki in Proceedings of the 3rd International Congr… (1991)

  7. No Access

    Chapter

    Alkaloids

    Despite the historic roles of colchicine (and certain of its derivatives) and, subsequently, of the Vinca alkaloids, not only as probes that have expanded our fundamental knowledge of cell biology, but also as im...

    W. T. Beck in Antitumor Drug Resistance (1984)

  8. No Access

    Chapter

    Why Is Tumor tRNA Hypomodified with Respect to Q Nucleoside?

    Nucleoside Q is found exclusively in the first position of the anticodon in tRNATyr, tRNAHis, tRNAAsn, and tRNAAsp (Kasai et al. 1975b, 1976). Its function is unknown, and long-term Q-deficient, germ-free mice ap...

    J. R. Katze, W. T. Beck, C. S. Cheng, J. A. McCloskey in Modified Nucleosides and Cancer (1983)