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Article
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX
A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.
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Article
Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan
We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 p...
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Article
Association between change in body weight after midlife and risk of hip fracture—the Singapore Chinese Health Study
The relationship between change in body weight and risk of fractures is inconsistent in epidemiologic studies. In this cohort of middle-aged to elderly Chinese in Singapore, compared to stable weight, weight l...
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Article
Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study
This prospective cohort study that comprehensively examined effects of different B vitamins in an Asian population showed an inverse relationship between dietary intake of pyridoxine and hip fracture risk in e...
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Article
All-cause and cause-specific mortality after hip fracture among Chinese women and men
All-cause mortality risk persisted for 5 years after hip fractures in both men and women. There may be gender-specific differences in effect and duration of excess risk for cause-specific mortality after hip f...
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Article
Open AccessDiabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study
The increasing prevalence of diabetes may contribute to the rising incidence of hepatocellular carcinoma (HCC) in the US and other developed countries where HCC incidence is relatively low. Data from prospecti...
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Article
Open AccessSmoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study
Given the close correlation between smoking and alcohol intake in most epidemiologic studies, it is difficult to exclude the residual confounding effect of alcohol in the association between smoking and hepato...
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Article
Open AccessSmoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese Health Study
Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the impact of smoking cessation on lung cance...
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Article
Open AccessBody mass index and smoking-related lung cancer risk in the Singapore Chinese Health Study
Smokers with low body mass index (BMI) may be more susceptible to lung cancer.
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Article
Open AccessProspective study of dietary patterns and colorectal cancer among Singapore Chinese
An influence of Western diet and lifestyle factors observed among Singapore Chinese may contribute to the population's marked rise in colorectal cancer incidence over the past two decades. Thus far, however, t...
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Article
Open AccessSoy intake and breast cancer risk in Singapore Chinese Health Study
We investigated the effects of soy isoflavone intake on breast cancer in a prospective study of 35 303 Singapore Chinese women enrolled during April 1993 to December 1998 in the Singapore Chinese Health Study....
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Article
Open AccessCigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study
The relations were examined between colorectal cancer and cigarette smoking and alcohol consumption within the Singapore Chinese Health Study, a population-based, prospective cohort of 63 257 middle-aged and o...
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Article
Epidemiology of pterygium on a tropical island in the Riau Archipelago
To describe the epidemiology of pterygium among residents of an island in Indonesia and to examine the roles of age and gender as determinants of bilaterality and severity of the disease.
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Article
Potential sources of carcinogenic heterocyclic amines in the Chinese diet: results from a 24-h dietary recall study in Singapore
Objective: Heterocyclic amines (HCAs) from high-temperature cooking of meat have been linked to increased cancer incidence in Western populations, but data on the sources of HCAs in Asian diets are scarce. Our ai...
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Article
Open AccessInteraction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: The Singapore Chinese Health Study
This case–control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the...
