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Global Healthspan Summit 2023: closing the gap between healthspan and lifespan
On 29–30 November 2023, the inaugural Global Healthspan Summit, convened in Riyadh by the nonprofit Hevolution Foundation, provided a dynamic platform that united experts from diverse sectors to foster collabo...
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Open AccessProtein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for A...
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Open AccessThe p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase ...
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Open AccessPhage display of functional αβ single-chain T-cell receptor molecules specific for CD1b:Ac2SGL complexes from Mycobacterium tuberculosis-infected cells
The development of molecules specific for M. tuberculosis-infected cells has important implications, as these tools may facilitate understanding of the mechanisms regulating host pathogen interactions in vivo. In...
