12 Result(s)
within
Vittoria D’Esposito
-
Article
Open AccessSerotoninergic receptor ligands improve Tamoxifen effectiveness on breast cancer cells
Serotonin (or 5-Hydroxytryptamine, 5-HT) signals in mammary gland becomes dysregulated in cancer, also contributing to proliferation, metastasis, and angiogenesis. Thus, the discovery of novel compounds target...
-
Article
Open AccessCytokine signature and COVID-19 prediction models in the two waves of pandemics
In Europe, multiple waves of infections with SARS-CoV-2 (COVID-19) have been observed. Here, we have investigated whether common patterns of cytokines could be detected in individuals with mild and severe form...
-
Article
In severe obesity, subcutaneous adipose tissue cell-derived cytokines are early markers of impaired glucose tolerance and are modulated by quercetin
Excessive adiposity provides an inflammatory environment. However, in people with severe obesity, how systemic and local adipose tissue (AT)-derived cytokines contribute to worsening glucose tolerance is not c...
-
Chapter
Gene-Environment Interaction and Cancer
It is widely recognized that cancer is an epigenetic disease. Hypomethylation of cytosine residues of CpG dinucleotides, site-specific CpG promoter hypermethylation, altered histone methylation and acetylation...
-
Article
Pro-inflammatory adipokine profile in psoriatic arthritis: results from a cross-sectional study comparing PsA subset with evident cutaneous involvement and subset “sine psoriasis”
Adipokines have been considered in the pathogenesis of the inflammatory processes of psoriatic arthritis (PsA). The main aim of the current study is to investigate possible differences and correlations between...
-
Article
Differences in Metabolic Factors Between Antipsychotic-Induced Weight Gain and Non-pharmacological Obesity in Youths
Youth exposed to antipsychotics may experience several metabolic consequences that often limit the effectiveness of this class of drugs.
-
Article
Erratum to: Ultrapure dialysis water obtained with additional ultrafilter may reduce inflammation in patients on hemodialysis
In original publication, the Table 4 was incorrect. The correct Table has been given below:
-
Article
Open AccessUltrapure dialysis water obtained with additional ultrafilter may reduce inflammation in patients on hemodialysis
Patients on standard dialysis, in particular those on high-flux and high-efficiency dialysis, are exposed to hundreds of liters of dialysis-water per week. The quality of dialysis-water is a factor responsible...
-
Article
Open AccessSpecific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity
Epigenetic modifications alter transcriptional activity and contribute to the effects of environment on the individual risk of obesity and Type 2 Diabetes (T2D). Here, we have estimated the in vivo effect of a fa...
-
Article
Open AccessDissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate
The metabolic syndrome (MetS) is a large-scale and expanding public-health and clinical threat worldwide. We investigated the determinants of MetS, assessed its prevalence and components and, estimated their g...
-
Article
Open AccessBisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population
The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic altera...
-
Article
Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo
Insulin exerts a direct action on vascular cells, thereby affecting the outcome and progression of diabetic vascular complications. However, the mechanism through which insulin signalling is impaired in the en...
