16 Result(s)
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Visish M. Srinivasan
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Article
Open AccessTenecteplase versus alteplase before stroke thrombectomy: outcomes after system-wide transitions in Pennsylvania
United States stroke systems are increasingly transitioning from alteplase (TPA) to tenecteplase (TNK). Real-world data on the safety and effectiveness of replacing TPA with TNK before large vessel occlusion (...
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Article
Middle meningeal artery patency after surgical evacuation for chronic subdural hematoma
Chronic subdural hematoma (CSDH) often requires surgical evacuation, but recurrence rates remain high. Middle meningeal artery (MMA) embolization (MMAE) has been proposed as an alternative or adjunct treatment...
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Article
Sex differences in patients with and without high-risk factors associated with aneurysmal subarachnoid hemorrhage
Controversy remains regarding the appropriate screening for intracranial aneurysms or for the treatment of aneurysmal subarachnoid hemorrhage (aSAH) for patients without known high-risk factors for rupture. Th...
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Article
Frailty in aneurysmal subarachnoid hemorrhage: the risk analysis index
Few studies have evaluated frailty in the setting of aneurysmal subarachnoid hemorrhage (aSAH) using large-scale data. The risk analysis index (RAI) may be implemented at the bedside or assessed retrospectivel...
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Article
Association between external ventricular drain removal or replacement and prophylactic anticoagulation in patients with aneurysmal subarachnoid hemorrhage: a propensity-adjusted analysis
Withholding prophylactic anticoagulation from patients with aneurysmal subarachnoid hemorrhage (aSAH) before external ventricular drain (EVD) removal or replacement remains controversial. This study analyzed w...
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Propensity-adjusted analysis of ultra-early aneurysmal subarachnoid hemorrhage treatment and patient outcomes
Optimal definitive treatment timing for patients with aneurysmal subarachnoid hemorrhage (aSAH) remains controversial. We compared outcomes for aSAH patients with ultra-early treatment versus later treatment a...
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Article
Surgical management outcomes of intracranial arteriovenous malformations after preoperative embolization: a systematic review and meta-analysis
Preoperative embolization for brain arteriovenous malformations (AVMs) has been shown to mitigate morbidity for high-risk AVMs, chiefly by reducing lesional blood flow before resection. However, associated ris...
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Article
Fourth-generation bypass and flow reversal to treat a symptomatic giant dolichoectatic basilar trunk aneurysm
Giant dolichoectatic basilar trunk aneurysms have an unfavorable natural history and are associated with high morbidity, but their neurosurgical treatment is complex and challenging.
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Article
Microsurgical treatment of ruptured aneurysms beyond 72 hours after rupture: implications for advanced management
Aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to primary stroke centers are often transferred to neurosurgical and endovascular services at tertiary centers. The effect on microsurgical outcomes ...
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Article
Research advances in the diagnosis and treatment of moyamoya disease: a bibliometric analysis
Moyamoya disease is a rare cerebrovascular condition involving stenotic carotid arteries and the formation of abnormal blood vessels. In this study, we aimed to characterize the key players involved in moyamoy...
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Brainstem Cavernous Malformations
Cavernous malformations (CMs) are a rare cerebrovascular anomaly that may arise from different regions of the central nervous system. Brainstem CMs (BSCMs) have unique clinical manifestations that require tail...
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Article
Treatment of octogenarians and nonagenarians with aneurysmal subarachnoid hemorrhage: a 17-year institutional analysis
Outcomes for octogenarians and nonagenarians after an aneurysmal subarachnoid hemorrhage (aSAH) are particularly ominous, with mortality rates well above 50%. The present analysis examines the neurologic outco...
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Article
Pediatric intracranial arterial injuries by penetrating gunshot wounds: an institutional experience
Pediatric intracranial injuries due to penetrating gunshot wounds are a rare entity that is often fatal. A subset of patients may experience an intracerebral arterial injury; however, literature on the pediatr...
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Article
Open AccessGastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature
Intracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literat...
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Article
Tumor Vaccines for Malignant Gliomas
Despite continued research efforts, glioblastoma multiforme (GBM) remains the deadliest brain tumor. Immunotherapy offers a novel way to treat this disease, the genetic signature of which is not completely elu...
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Article
The role of STAT3 in tumor-mediated immune suppression
The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immuno...
