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Article
What’s new in the treatment of acute migraine
With the rapid advances in the treatment of migraine attacks in the last few years, a number of non-specific anti-migraine drugs have been developed for clinical use. The most important class of drugs for the ...
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Article
Dysimmune disorders and migraine: is there a possible common denominator?
The association between headache, especially migraine, and some immunomediated diseases, in particular autoimmune diseases, is well known. The evidence in favor of this association comes prevailingly from epid...
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Article
Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population
A multicenter one-year study was carried out on 6629 headache patients under 18 years of age, attending 27 centers and clinics devoted to headache in Italy to identify the prevalence of cluster headache (CH) i...
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Article
An open-label pilot study on the efficacy and tolerability of levetiracetam in the prophylaxis of migraine
A preliminary, open label study was conducted on 20 patients with migraine without aura and with high headache frequency to assess the efficacy and tolerability of the new antiepileptic drug levetiracetam. Pat...
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Article
Selection of thrombogenetic antiphospholipid antibodies in cerebrovascular disease patients
Background and Purpose: The association between anticardiolipin antibodies (aCL) and thrombosis is well recognized, but its role as an independent risk factor for stroke is not. The study's aim was to investigat...
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Article
Electromyographical ischemic test, clinical symptoms related to neuromuscular hyperexcitability, and intra- and extracellular Mg++ levels in headache patients
We observed the occurrence of neuromuscular hyperexcitability, assessed with electromyographic ischemic tests, in headache patients in relation to Mg++ levels in serum, red blood cells and mononuclear cells. Cli...
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Article
Brain-derived neurotrophic factor in cerebrospinal fluid of patients with chronic daily headache: relationship with nerve growth factor and glutamate levels
Little has been done to investigate the biochemical basis of chronic daily headache (CDH). Our group has recently demonstrated an increase in the cerebrospinal fluid (CSF) levels of nerve growth factor (NGF) ...
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Article
Headache and ischemic stroke
Migraine is a common neurological condition affecting yearly 1%–10% of all men and 3%–20% of all women. Focal neurological symptoms (auras), most commonly visual and sensory, occur in 4% of migraine attacks. M...
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Article
Diagnostic and therapeutic guidelines for migraine. Italian Society for the Study of Headaches (SISC)
The Italian Society for the Study of Headaches (SISC) published the first guidelines for diagnosis and treatment of migraine in 1993. In 2000, the Executive Committee of the SISC decided to provide updated dia...
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Article
Platelets in migraine
Modification in platelet activation and aggregation has been demonstrated in migraine patients both during and between attacks. A different pattern in the secretion of platelet products has also been observed ...
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Article
Clinical and genetic analysis of an Italian family with Machado-Joseph disease
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Article
Headache associated with acute ischemic stroke
Headache occurs frequently in acute ischemic stroke, but its frequency varies widely among different studies. We have prospectively studied headache features in patients with first-ever ischemic acute stroke ...
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Article
The importance of anxiety and depression as factors in chronicization of primary headaches
A multicenter study was carried out in 10 Italian headache centers to investigate the prevalence of anxiety and depression in patients with chronic daily headache(CDH). The study investigated 219 patients (17...
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Article
Clinical and descriptive analysis of chronic daily headaches
With an ad hoc, previously validated clinical record, we analysed the headache characteristics in 245 patients (F, 78.4%, M, 21,6%; mean age, 43.1±12.9 years) affected by chronic daily headache (CDH) attendin...
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Article
Chronic daily headache: biochemical and neurotransmitter abnormalities
Although chronic daily headache (CDH) represents one of the most relevant complaints of patients in headache centers, the mechanisms underlying the chronicization of head pain are poorly understood. Experimen...
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Article
Nitric oxide in primary headaches
Nitric oxide (NO) has been proposed to be a key molecule in migraine. Experimental evidence suggests its intervention in vasodilatation and activation of the trigeminovascular system as well as its involvemen...
