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Article
Pharmacophore and 3d-Qsar Modeling of new 1,3,4-Thiadiazole Derivatives: Specificity to Colorectal Cancer
Interleukin-6 (IL-6) is the new molecular target to treat colorectal cancer (CRC) for investigation of potential lead molecules. The main objective of this study was to develop the three-dimensional quantitati...
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Article
Open AccessAuthor Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessNovel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular ca...
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Article
ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was esti...
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Article
Design and synthesis of 4-(4-ethyl-phenyl)-4-oxo-butyric acid (3-oxo-1, 3-diphenyl-propylidene)/[1-(4-chloro-phenyl)-ethylidene]-hydrazide as potential anticonvulsant agents
Some new substituted hydrazone derivatives were designed, synthesized, and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established after intrapentoneal administrati...