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Article
Open AccessExploring C4–CAM plasticity within the Portulaca oleracea complex
Portulaca oleracea is a C4 herb capable of performing CAM under drought stress. It is distributed worldwide and is either considered a polymorphic species or a complex of subspecies, due to its numerous morpholog...
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Article
Open AccessPreadult polytoxicomania—strong environmental underpinnings and first genetic hints
Considering the immense societal and personal costs and suffering associated with multiple drug use or “polytoxicomania”, better understanding of environmental and genetic causes is crucial. While previous stu...
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Article
Open AccessAddressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues
Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...
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Article
Open AccessBrain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive actions, that presents the involvement of the cortico-striatal areas. The contribution of environmental risk factors to...
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Article
Open AccessGestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure
Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into p...
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Article
Open AccessErythropoietin re-wires cognition-associated transcriptional networks
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we pr...