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  1. Article

    Open Access

    Exploring C4–CAM plasticity within the Portulaca oleracea complex

    Portulaca oleracea is a C4 herb capable of performing CAM under drought stress. It is distributed worldwide and is either considered a polymorphic species or a complex of subspecies, due to its numerous morpholog...

    Renata Callegari Ferrari, Bruna Coelho Cruz in Scientific Reports (2020)

  2. Article

    Open Access

    Preadult polytoxicomania—strong environmental underpinnings and first genetic hints

    Considering the immense societal and personal costs and suffering associated with multiple drug use or “polytoxicomania”, better understanding of environmental and genetic causes is crucial. While previous stu...

    Agnes A. Steixner-Kumar, Vinicius Daguano Gastaldi, Jan Seidel in Molecular Psychiatry (2021)

  3. Article

    Open Access

    Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues

    Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...

    Martin Begemann, Oliver Gross, Dominik Wincewicz, Rüdiger Hardeland in Molecular Medicine (2021)

  4. Article

    Open Access

    Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation

    Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive actions, that presents the involvement of the cortico-striatal areas. The contribution of environmental risk factors to...

    Kátia Cristina de Oliveira, Caroline Camilo, Vinícius Daguano Gastaldi in BMC Genomic Data (2021)

  5. Article

    Open Access

    Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure

    Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into p...

    Verônica Euclydes, Catarina Gomes, Gisele Gouveia in Clinical Epigenetics (2022)

  6. Article

    Open Access

    Erythropoietin re-wires cognition-associated transcriptional networks

    Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we pr...

    Manvendra Singh, Ying Zhao, Vinicius Daguano Gastaldi in Nature Communications (2023)