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Article
Open AccessUncovering the burden of Influenza in children in Portugal, 2008–2018
Despite their higher risk of develo** severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical an...
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Article
“Metallic tulip bundle” technique as rescue hemostatic therapy after endoscopic mucosal resection of a gastric lesion
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Article
Open AccessST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility
Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation of cancer cells, and largely associates with their invasive and metastatic properties. Glycoproteins and glycolipi...
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Reference Work Entry In depth
Job Core Performance Measures
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Article
Open AccessGestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure
Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into p...
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Article
Open AccessExcess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
Influenza can have a domino effect, triggering severe conditions and leading to hospitalization or even death. Since influenza testing is not routinely performed, statistical modeling techniques are increasing...
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Article
Open AccessFatal haemorrhage from a lower limb varicose vein rupture: two case reports
Chronic venous disease is one of the most prevalent pathologies today. In Portugal, as in other western countries, its prevalence is high, affecting around 35% of the adult population. It is a chronic and prog...
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Living Reference Work Entry In depth
Job Core Performance Measures
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Article
Terminal α2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells
The epidermal growth factor receptor (EGFR) is a key protein involved in cancer development. Monoclonal antibodies targeting EGFR are approved for the treatment of metastatic colorectal cancer (CRC). Despite t...
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Article
Open AccessST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab
The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the emergence of molecular resistance. Tr...
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Article
Open AccessClinicopathological and imaging features of pulmonary alveolar microlithiasis in a dog – a case report
The aetiology of pulmonary alveolar microlithiasis (PAM) in animals is still unknown. In humans, this pulmonary disorder is a rare autosomal recessive disorder triggered by a mutation in the gene SLC34A2, whic...
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Article
Open AccessGenomic imbalances defining novel intellectual disability associated loci
High resolution genome-wide copy number analysis, routinely used in clinical diagnosis for several years, retrieves new and extremely rare copy number variations (CNVs) that provide novel candidate genes contr...
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Article
The GAGOme: a cell-based library of displayed glycosaminoglycans
Glycosaminoglycans (GAGs) are essential polysaccharides in normal physiology and disease. However, understanding of the contribution of specific GAG structures to specific biological functions is limited, larg...
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Article
Open AccessProceedings of the 3rd IPLeiria’s International Health Congress
S1 Health literacy and health education in adolescence
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Article
Open AccessTraining for happiness: the impacts of different positive exercises on hedonism and eudaemonia
Theoretical conceptions on happiness have generally considered two broad perspectives: hedonic enjoyment and eudaemonia. However, most research on how to improve people’s happiness has focused primarily on th...
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Chapter and Conference Paper
Improving Production Logistics Through Materials Flow Control and Lot Splitting
Competitive advantage of make-to-order manufacturing companies is highly dependent on their capability to offer short delivery times and on time delivery. This calls for effective production and materials flo...
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Chapter
Role of Adenosine A2A Receptors in the Control of Neuroinflammation—Relevance for Parkinson’s Disease
The antagonism of adenosine A2A receptors (A2AR) is currently a leading non-dopaminergic strategy to delay the onset of Parkinson’s disease (PD), but the underlying mechanism of action is still unclear. One promi...
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Article
Open AccessEvaluation of time in therapeutic range in anticoagulated patients: a single-center, retrospective, observational study
The percentage of time during which the patients have the INR within the target values (i.e. Time in Therapeutic Range [TTR]) is a measure of anticoagulation quality with Vitamin K Antagonists (VKA). To evalua...
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Article
Open AccessAberrant P-cadherin expression is associated to aggressive feline mammary carcinomas
Cadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by l...
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Article
Open AccessActivation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
Brain-derived neurotrophic factor (BDNF) has been shown to control microglial responses in neuropathic pain. Since adenosine A2A receptors (A2ARs) control neuroinflammation, as well as the production and function...
