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Article
Neuron-restrictive silencer elements mediate neuron specificity of adenoviral gene expression
Neuron–restrictive silencer elements (NRSEs) were used to target the gene expression of adenoviral vectors specifically to neuron cells in the central nervous system. By generating adenoviral constructs in whi...
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Chapter and Conference Paper
Patient-specific seizure prediction using a multi-feature and multi-modal EEG-ECG classification
Epilepsy, a neurological disorder in which patients suffer from recurring seizures, affects approximately 1% of the world population. In spite of available drug and surgical treatment options, more than 25% of...
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Article
Incidence and risk factors for seizures after heart transplantation
Neurological complications can occur after heart transplantation and present with seizures. We examined the incidence of seizures from a population of adult patients who had received heart transplants over a p...
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Article
Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature
Yanick Crow and colleagues show that mutations in ACP5, which encodes tartrate-resistant acid phosphatase, cause spondyloenchondrodysplasia, a bone dysplasia with autoimmunity. The affected individuals had elevat...
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Article
What is Specialized Care in Status Epilepticus and in Which ICU?
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Chapter
Brainatic: A System for Real-Time Epileptic Seizure Prediction
A new system developed for real-time scalp EEG-based epileptic seizure prediction is presented, based on real time classification by machine learning methods, and named Brainatic. The system enables the consid...
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Article
Safety profile of intracranial electrode implantation for video-EEG recordings in drug-resistant focal epilepsy
Invasive electroencephalography recordings with depth or subdural electrodes are necessary to identify the ictogenic area in some drug-resistant focal epilepsies. We aimed to analyze the safety profile of intr...
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Article
Open AccessSpondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey
Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohor...
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Article
Erratum to: Spondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey
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Article
Open AccessEfficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial
Generalized tonic-clonic seizures (GTCSs) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Experimental and clinical data strongly suggest that the majority of SUDEP results from a pos...
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Article
Open AccessVoluntary control of intracortical oscillations for reconfiguration of network activity
Voluntary control of oscillatory activity represents a key target in the self-regulation of brain function. Using a real-time closed-loop paradigm and simultaneous macro- and micro-electrode recordings, we stu...
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Article
Open AccessCognitive dissonance resolution depends on episodic memory
The notion that past choices affect preferences is one of the most influential concepts of social psychology since its first report in the 50 s, and its theorization within the cognitive dissonance framework. ...
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Article
Medial temporal lobe epilepsy associated with hippocampal sclerosis is a distinctive syndrome
Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal s...
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Article
Understanding Lennox–Gastaut syndrome: insights from focal epilepsy patients with Lennox–Gastaut features
To delineate the clinical and EEG features of adults with focal epilepsy associated with a generalized paroxysmal fast activity (GPFA) pattern on EEG who developed refractory seizures, notably drop attacks, bu...
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Article
Open AccessAdolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes
5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clini...
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Article
Open AccessValue and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness: a systematic review
Electroencephalography (EEG) is a well-established tool for assessing brain function that is available at the bedside in the intensive care unit (ICU). This review aims to discuss the relevance of electroencep...
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Article
Four core properties of the human brain valuation system demonstrated in intracranial signals
Estimating the value of alternative options is a key process in decision-making. Human functional magnetic resonance imaging and monkey electrophysiology studies have identified brain regions, such as the vent...
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Article
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study
The common co-occurrence of autoimmune systemic diseases in patients with neurological disorders and antibodies against glutamic acid decarboxylase 65 (GAD65) suggests a shared genetic predisposition to these ...
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Article
Open AccessA self-supervised learning strategy for postoperative brain cavity segmentation simulating resections
Accurate segmentation of brain resection cavities (RCs) aids in postoperative analysis and determining follow-up treatment. Convolutional neural networks (CNNs) are the state-of-the-art image segmentation tech...
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Article
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures
Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. Mutations of LGI1 have been linked to aut...
