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    Article

    Intercalated cell function, kidney innate immunity, and urinary tract infections

    Intercalated cells (ICs) in the kidney collecting duct have a versatile role in acid–base and electrolyte regulation along with the host immune defense. Located in the terminal kidney tubule segment, ICs are a...

    Andrew L. Schwaderer, Evan Rajadhyaksha in Pflügers Archiv - European Journal of Phys… (2024)

  2. Article

    Open Access

    Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

    Kidney intercalated cells are involved in acid-base homeostasis via vacuolar ATPase expression. Here we report six human intercalated cell subtypes, including hybrid principal-intercalated cells identified fro...

    Vijay Saxena, Hongyu Gao, Samuel Arregui, Amy Zollman in Nature Communications (2021)

  3. Article

    Open Access

    Publisher Correction: Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Vijay Saxena, James Fitch, John Ketz, Peter White, Amy Wetzel in Scientific Reports (2020)

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    Article

    Adolescents with urinary stones have elevated urine levels of inflammatory mediators

    Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a me...

    Kirsten Kusumi, John Ketz, Vijay Saxena, John David Spencer, Fayez Safadi in Urolithiasis (2019)

  5. Article

    Open Access

    Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function

    The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs). We have previously demonstrated that collecting ducts have a role in the innate immune defense of the kidney. Transcrip...

    Vijay Saxena, James Fitch, John Ketz, Peter White, Amy Wetzel in Scientific Reports (2019)

  6. Article

    Open Access

    Characterization of mixed lymphocyte reaction blocking antibodies (MLR-Bf) in human pregnancy

    It is known that during normal pregnancy and after immunotherapy blocking antibodies are developed, these antibodies inhibit mixed lymphocyte reaction and are also anti-mitogenic in nature. Mixed lymphocyte re...

    Manoj Kumar Pandey, Vijay Saxena, Suraksha Agrawal in BMC Pregnancy and Childbirth (2003)