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Article
Mitochondrial fission inhibition protects against hypertension induced by angiotensin II
Mitochondrial dysfunction has been implicated in various types of cardiovascular disease including hypertension. Mitochondrial fission fusion balance is critical to mitochondrial quality control, whereas enhan...
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Article
Shear Stress Activates eNOS at the Endothelial Apical Surface Through β1 Containing Integrins and Caveolae
There is now a large body of evidence demonstrating that fluid mechanical forces generated by blood flowing through the vasculature play a direct role in regulating endothelial cell structure and function. Int...
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Article
Open AccessChronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of soluble guanylyl cyclase
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Article
A physiologically realistic in vitro model of microvascular networks
Existing microfluidic devices, e.g. parallel plate flow chambers, do not accurately depict the geometry of microvascular networks in vivo. We have developed a synthetic microvascular network (SMN) on a polydimeth...