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    Noncanonical open reading frames encode functional proteins essential for cancer cell survival

    Although genomic analyses predict many noncanonical open reading frames (ORFs) in the human genome, it is unclear whether they encode biologically active proteins. Here we experimentally interrogated 553 candi...

    John R. Prensner, Oana M. Enache, Victor Luria, Karsten Krug… in Nature Biotechnology (2021)