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  1. No Access

    Article

    Cardiovascular and renal outcomes in patients with atrial fibrillation and stage 4–5 chronic kidney disease receiving direct oral anticoagulants: a multicenter retrospective cohort study

    The role of direct oral anticoagulants (DOAC) in patients with atrial fibrillation (AF) and stage 4–5 chronic kidney disease (CKD) is controversial. Electronic medical records from 2012 to 2021 were retrieved ...

    Yuan Lin, Tze-Fan Chao, Ming-Lung Tsai in Journal of Thrombosis and Thrombolysis (2024)

  2. No Access

    Article

    Prognostic Effects of Liver Fibrosis and Steatosis Determined Using Transient Elastography in Patients with Chronic Hepatitis B or C

    The prognostic effects of liver fibrosis and steatosis in patients with chronic hepatitis B or C are unclear. We investigated the prognostic effects of liver fibrosis and steatosis determined through transient...

    Chun-Li Wang, Chien-Hao Huang, Victor Chien-Chia Wu in Digestive Diseases and Sciences (2023)

  3. Article

    Open Access

    Sex differences in utilisation of extracorporeal membrane oxygenation support and outcomes in Taiwan

    The impact of sex-related differences in patients receiving extracorporeal membrane oxygenation support (ECMO) support is still inconclusive. This population-based study aimed to investigate sex differences in...

    Feng-Cheng Chang, An-Hsun Chou, Yu-Tung Huang, Jhen-Ling Huang in BMC Anesthesiology (2023)

  4. Article

    Open Access

    The cardiovascular and renal effects of glucagon-like peptide 1 receptor agonists in patients with advanced diabetic kidney disease

    To determine whether glucagon-like peptide 1 receptor agonists (GLP-1RAs) have cardiovascular and renal protective effects in patients with advanced diabetic kidney disease (DKD) with an estimated glomerular f...

    Yuan Lin, Te-Hsiung Wang, Ming-Lung Tsai in Cardiovascular Diabetology (2023)

  5. Article

    Open Access

    Surgical volume and outcomes of surgical ablation for atrial fibrillation: a nationwide population-based cohort study

    Atrial fibrillation is the most common cardiac arrythmia and causes many complications. Sinus rhythm restoration could reduce late mortality of atrial fibrillation patients. The Maze procedure is the gold stan...

    Feng-Cheng Chang, Yu-Tung Huang, Victor Chien-Chia Wu in BMC Cardiovascular Disorders (2023)

  6. No Access

    Article

    Risk of major bleeding associated with concomitant use of anticancer drugs and direct oral anticoagulant in patients with cancer and atrial fibrillation

    This study evaluated the risk of major bleeding associated with concomitant use of direct oral anticoagulant (DOAC) and anticancer drugs (ACDs), which share metabolic pathways, in patients with atrial fibrilla...

    Chun-Li Wang, Victor Chien-Chia Wu, Hui-Tzu Tu in Journal of Thrombosis and Thrombolysis (2022)

  7. Article

    Open Access

    Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome

    No study has evaluated the effect of dexmedetomidine in patients who received surgery for type A aortic dissection. This is the first study to evaluate the effect of dexmedetomidine in aortic dissection patien...

    Yu-Ting Cheng, Kuang-Tso Lee, Chih-Hsiang Chang, Victor Chien-Chia Wu in Scientific Reports (2022)

  8. Article

    Open Access

    A validation study comparing existing prediction models of acute kidney injury in patients with acute heart failure

    Acute kidney injury (AKI) is a common complication in acute heart failure (AHF) and is associated with prolonged hospitalization and increased mortality. The aim of this study was to externally validate existi...

    Tao Han Lee, Pei-Chun Fan, Jia-** Chen, Victor Chien‐Chia Wu in Scientific Reports (2021)

  9. No Access

    Article

    Atrial fibrillation and associated outcomes in patients with peritoneal dialysis and hemodialysis: a 14-year nationwide population-based study

    Patients with end-stage renal disease (ESRD) undergoing dialysis have increased risks of atrial fibrillation (AF).

    Chih-Hsiang Chang, Pei-Chun Fan, Yu-Sheng Lin, Shao-Wei Chen in Journal of Nephrology (2021)

  10. No Access

    Article

    Incidence and consequences of resuming oral anticoagulant therapy following hematuria and risks of ischemic stroke and major bleeding in patients with atrial fibrillation

    Following hematuria, it is uncertain to what extent a vitamin K antagonist (VKA) or non-VKA oral anticoagulant (NOAC) is resumed, and the risks of ischemic stroke/systemic embolism and major bleeding associate...

    Chun-Li Wang, Victor Chien-Chia Wu, Yu-Tung Huang in Journal of Thrombosis and Thrombolysis (2021)

  11. Article

    Open Access

    Sodium-glucose cotransporter 2 inhibitor versus metformin as first-line therapy in patients with type 2 diabetes mellitus: a multi-institution database study

    Sodium-glucose co-transporter 2 inhibitors (SGLT2i) has shown evidence of cardiovascular benefit in patients with type 2 diabetes mellitus (T2DM). Currently metformin is the guideline-recommended first-line tr...

    Tien-Hsing Chen, Yan-Rong Li, Shao-Wei Chen, Yu-Sheng Lin in Cardiovascular Diabetology (2020)

  12. Article

    Open Access

    Association between initial dialytic modalities and the risks of mortality, infection death, and cardiovascular events: A nationwide population-based cohort study

    To date, few studies have been conducted to pairwise compare the prognosis of peritoneal dialysis (PD), unplanned PD, and unplanned hemodialysis (HD). We analyzed longitudinal data from Taiwan’s National Healt...

    Yi-Ran Tu, Tsung-Yu Tsai, Ming-Shyan Lin, Kun-Hua Tu, Cheng-Chia Lee in Scientific Reports (2020)

  13. Article

    Open Access

    Long-term Outcome of Neurological Complications after Infective Endocarditis

    Severe neurological complications following infective endocarditis remain a major problem with high mortality rate. The long-term neurological consequences following infective endocarditis remain uncertain. Ot...

    Ching-Chang Chen, Victor Chien-Chia Wu, Chien-Hung Chang in Scientific Reports (2020)

  14. Article

    Open Access

    Analysis of survival after initiation of continuous renal replacement therapy in patients with extracorporeal membrane oxygenation

    No study has specifically investigated the duration of continuous renal replacement therapy (CRRT) in patients who experienced acute kidney injury during extracorporeal membrane oxygenation (ECMO) support. How...

    George Kuo, Shao-Wei Chen, Pei-Chun Fan, Victor Chien-Chia Wu in BMC Nephrology (2019)

  15. No Access

    Article

    Effectiveness and safety of non-vitamin-K antagonist oral anticoagulants versus warfarin in atrial fibrillation patients with thrombocytopenia

    Patients with thrombocytopenia were excluded from major clinical trials that investigated non-vitamin-K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation (AF). The aim of this...

    Chun-Li Wang, Victor Chien-Chia Wu in Journal of Thrombosis and Thrombolysis (2019)

  16. No Access

    Article

    Serum asprosin levels and bariatric surgery outcomes in obese adults

    Asprosin is a novel fasting-induced glucogenic and orexigenic protein hormone. The clinical function of asprosin in obesity is currently unknown. This study investigated the association between asprosin abunda...

    Chao-Yung Wang, Tien-An Lin, Keng-Hau Liu in International Journal of Obesity (2019)

  17. Article

    Open Access

    Red cell distribution width associated with adverse cardiovascular outcomes in patients with chronic kidney disease

    Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RD...

    Yueh-An Lu, Pei-Chun Fan, Cheng-Chia Lee, Victor Chien-Chia Wu in BMC Nephrology (2017)

  18. Article

    Open Access

    Phenotypic expressions of hereditary Transthyretin Ala97Ser related Amyloidosis (ATTR) in Taiwanese

    The disease course and early signs specific to ATTR Ala97Ser, the most common endemic mutation in Taiwan, have not been well described. Since new medications can slow down the rate of disease progression, the ...

    Hui-Ching Hsu, Ming-Feng Liao, Jung-Lung Hsu, Ai-Lun Lo, Hung-Chou Kuo in BMC Neurology (2017)