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Article
Open AccessClimate model selection via conformal clustering of spatial functional data
Climate model selection stands as a critical process in climate science and research. It involves choosing the most appropriate climate models to address specific research questions, simulating climate behavio...
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Article
Open AccessChlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2
Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome - only partially effective with current schemes - places this disease among the unmet medical needs, and effective ther...
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Article
Open AccessThe Molecular Tumor Board of the Regina Elena National Cancer Institute: from accrual to treatment in real-world
Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration map**, and outcome metrics. These topics are addressed herein in 124...
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Article
Open AccessThe Glioma-IRE project − Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach
This study aimed to characterize the genetic profile of patients with glioma and discuss the impact of next-generation sequencing in glioma diagnosis and treatment.
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Article
Open AccessA diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
Altered microRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a stable form thus representing interesting biomarker candidates. This study aimed to iden...
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Article
COV-BT Ire study: safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with brain tumors
The BNT162b2 vaccine conferred 95% protection against COVID-19 in people aged 16 years or older.
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Article
Open AccessChlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
Glioblastoma (GBM; grade IV glioma) is characterized by a very short overall survival time and extremely low 5-year survival rates. We intend to promote experimental and clinical research on rationale and scie...
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Open AccessRepurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps
Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgic...
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Article
Correction to: Phase II study of weekly carboplatin in pretreated adult malignant gliomas
In the original article, the names of authors Mariantonia Carosi and Tatiana Koudriavtseva were incorrectly captured, and author Francesco Cognetti's affiliation was incorrect. The information is correctly sho...
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Article
Open AccessOverexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study
Cancer is a mosaic of tumor cell subpopulations, where only a minority is responsible for disease recurrence and cancer invasiveness. We focused on one of the most aggressive circulating tumor cells (CTCs) whi...
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Article
Open AccessA restricted signature of serum miRNAs distinguishes glioblastoma from lower grade gliomas
Malignant gliomas are the most common primary brain tumors in adults and challenging cancers for diagnosis and treatment. They remain a disease for which non-invasive, diagnostic and/or prognostic novel biomar...
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Article
Open AccessEfficacy and tolerability of pregabalin as preventive treatment for migraine: a 3-month follow-up study
Migraine is a common neurological disorder and epidemiological studies have documented its high social and economic impact. Unfortunately, preventive treatment is often insufficient to substantially reduce mig...
