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Article
Esrrb guides naive pluripotent cells through the formative transcriptional programme
During embryonic development, naive pluripotent epiblast cells transit to a formative state. The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and epigenetic profiles a...
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Article
Open AccessBrewerIX enables allelic expression analysis of imprinted and X-linked genes from bulk and single-cell transcriptomes
Genomic imprinting and X chromosome inactivation (XCI) are two prototypical epigenetic mechanisms whereby a set of genes is expressed mono-allelically in order to fine-tune their expression levels. Defects in ...
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Article
Metabolic control of DNA methylation in naive pluripotent cells
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 signaling induces genomic ...
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Article
Erratum: A transcription factor–based mechanism for mouse heterochromatin formation
Nat. Struct. Mol. Biol. 19, 1023–1030 (2012); published online 16 September 2012; corrected after print 27 December 2012 In the version of this article initially published, Simone Meidhof's affiliations should...
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Article
A transcription factor–based mechanism for mouse heterochromatin formation
The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a pathway in which transcriptional repression of pericen...
