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Article
Anti-inflammatory and antioxidant activities of ginsenosides and ginseng root extract to counteract obesity
The objective of this research was to study the possible effects of ginsenosides and ginseng root extract against inflammation and oxidation, classic conditions in obese patients. Different procedures for gins...
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Article
Open AccessImmortalized Alzheimer’s Disease Astrocytes: Characterization of Their Proteolytic Systems
Alzheimer’s disease (AD) is a progressive neurodegeneration with dysfunctions in both the ubiquitin–proteasome system (UPS) and autophagy. Astroglia participation in AD is an attractive topic of research, but ...
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Article
Open AccessStructure/activity virtual screening and in vitro testing of small molecule inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from gut methanogenic bacteria
Virtual screening techniques and in vitro binding/inhibitory assays were used to search within a set of more than 8,000 naturally occurring small ligands for candidate inhibitors of 8-hydroxy-5-deazaflavin:NAD...
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Article
Open AccessKiller yeasts exert anti-plasmodial activities against the malaria parasite Plasmodium berghei in the vector mosquito Anopheles stephensi and in mice
Wickerhamomyces anomalus is a yeast associated with different insects including mosquitoes, where it is proposed to be involved in symbiotic relationships with hosts. Different symbiotic strains of W. anomalus di...
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Article
Open AccessSLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model
The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a nov...
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Article
Open AccessInterfering with the high-affinity interaction between wheat amylase trypsin inhibitor CM3 and toll-like receptor 4: in silico and biosensor-based studies
Wheat amylase/trypsin bi-functional inhibitors (ATIs) are protein stimulators of innate immune response, with a recently established role in promoting both gastrointestinal and extra-gastrointestinal inflammat...
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Article
Open AccessMicrobiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous sys...
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Article
The fine-tuning of proteolytic pathways in Alzheimer’s disease
Several integrated proteolytic systems contribute to the maintenance of cellular homeostasis through the continuous removal of misfolded, aggregated or oxidized proteins and damaged organelles. Among these sys...
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Article
Effects of Ghrelin on the Proteolytic Pathways of Alzheimer’s Disease Neuronal Cells
Ghrelin is an orexigenic hormone with a role in the onset and progression of neurodegenerative disorders. It has been recently associated to Alzheimer’s disease (AD) for its neuroprotective and anti-apoptotic ...
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Article
Open AccessA yeast strain associated to Anopheles mosquitoes produces a toxin able to kill malaria parasites
Malaria control strategies are focusing on new approaches, such as the symbiotic control, which consists in the use of microbial symbionts to prevent parasite development in the mosquito gut and to block the t...
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Article
Ghrelin induces apoptosis in colon adenocarcinoma cells via proteasome inhibition and autophagy induction
Ghrelin is a metabolism-regulating hormone recently investigated for its role in cancer survival and progression. Controversially, ghrelin may act as either anti-apoptotic or pro-apoptotic factor in different ...
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Article
The relationship between the 20S proteasomes and prion-mediated neurodegenerations: potential therapeutic opportunities
The dysfunction of cellular degradation pathways of aberrant and misfolded proteins is a critical event in the onset of neurodegenerative disorders. Among these pathologies, prion diseases are a unique class o...
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Article
Decreased RNA, and Increased RNA Oxidation, in Ribosomes from Early Alzheimer’s Disease
All cells rely on efficient protein synthesis in order to maintain cellular homeostasis. Recent studies from our laboratory indicate that declines in protein synthesis and ribosome function occur in the earlie...
