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Article
Abnormalities in sarcolemmal phospholipase D and phospholipase C isoenzymes and in their interactions in post-infarcted failing hearts
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Chapter
The roles of free radicals, peroxides and oxidized lipoproteins in second messenger system dysfunction
In living tissue, cells are constantly exposed to a wide variety of sources of oxidative stress under both physiologic and pathologic situations [1]. In most circumstances, the cell’s built-in defense mechanis...
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Chapter
Phospholipase D: A New Avenue to the Phospholipid Signalling Pathways in the Myocardium
Over the past decade it has become known that phospholipids, present in the plasma membrane, play an essential part in receptor signal transduction. Firstly, changes in plasma membrane phospholipid composition...
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Chapter
Cardiac Phosphatidylethanolamine N-Methylation in Normal and Diabetic Rats Treated with L-Propionylcarnitine
The mitochondrial oxidation of long-chain fatty acids is a major pathway for energy production in the heart. L-carnitine, a naturally occurring highly polar compound, is essential for transporting long-chain f...
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Chapter
Subcellular Alterations in Hypertrophied Pig Heart Due to Pressure Overload
It is well known that Ca2+ plays a crucial role in determining the heart function and cellular integrity.1–5 While the interaction of Ca2+ with myofibrillar proteins is of prime importance in eliciting the contra...
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Chapter
Role of Phosphatidylethanolaminb N-Methylation on Ca2+ Transport in Cardiac Membranes
Evidence is accumulating that lipid composition of the membrane plays an important role in a variety of membrane-mediated functions of the myocardial cell, including the activities of membrane-bound enzymes an...
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Article
A biphasic change in contractile proteins during the development of cardiac hypertrophy in pigs
A non-failing hypertrophy of the left ventricle was produced in the pig heart by supravalvular banding of aorta for 4, 8 and 12 weeks and the myosin and myofibrillar adenosine triphosphatase activities were me...
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Chapter
Sarcolemmal Alterations during Catecholamine Induced Cardiomyopathy
Circulating levels of catecholamines are increased dramatically under stressful conditions and these hormones are generally considered responsible for the development of stress-associated cardiomyopathy. In fa...
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Chapter
Mitochondrial Oxidative Phosphorylation and Calcium Transport in Cardiac Hypertrophy due to Pressure Overload in Pigs
By virtue of their ability to generate energy in the form of ATP, mitochondria are known to play an important role in the maintenance of cardiac function (1). In addition, heart mitochondria have a remarkable ...
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Chapter
Sarcolemmal Alterations in Cardiac Hypertrophy Due to Pressure Overload in Pigs
Sarcolemma is considered to play an important role in raising and lowering the intracellular concentration of calcium for cardiac contraction and relaxation, respectively (1–4). Binding of Ca2+ with sarcolemma! m...
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Chapter and Conference Paper
Cardiac muscle function during the development of hypertrophy in pigs due to pressure overload
Myocardial contractile function was assessed in a chronic, slowly develo** hypertrophy in pigs in order to approximate more closely the situation seen in patients with heart hypertrophy due to pressure overl...
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Article
Calcium movements in relation to heart function
It is widely recognized that calcium is of singular importance in the viability of the myocardial cell, nonetheless little is known concerning the precise nature of the action of calcium in myocardium as to ho...
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Chapter
Subcellular changes during cardiac hypertrophy and heart failure due to bacterial endocarditis
Rabbits were catheterized and injected with saline (uninfected) or Streptococcus viridans (infected) to study the time course of changes in heart function, ultrastructure, membrane systems, myofibrils, and myocar...
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Article
Subcellular changes during cardiac hypertrophy and heart failure due to bacterial endocarditis
Rabbits were catheterized and injected with saline (uninfected) orStreptococcus viridans (infected) to study the time course of changes in heart function, ultrastructure, membrane systems, myofibrils, and myocard...
