25 Result(s)

Article

Effect of the Ac-D-MPRG Peptide Based on the C-Terminal Fragment of Arginine-Vasopressin(6–9) on the Behavior of Rats of Different Ages

It was found that Ac-D-MPRG, a tetrapeptide synthesized on the basis of the C-terminal fragment of arginine-vasopressin(6–9), affects anxiety and orienting-exploratory behavior in rats of all three studied age...

A. A. Stakhanova, O. G. Voskresenskaya… in Moscow University Biological Sciences Bull… (2023)

Article

Synthesis and Investigation of the Antidepressant Properties of Novel Analogs of Arginine-Vasopressin

A search for novel antidepressant analogs of arginine-vasopressin (AVP) by a computer modeling revealed the following peptide analogs of the C-terminal part of AVP: N-Ac-D-Ser-Pro-D-Arg-Gly-NH₂, N-Ac-Phe-Pro-Arg-...

K. V. Borodina, O. N. Savanets, E. S. Pustyulga… in Russian Journal of Bioorganic Chemistry (2022)

Article

Modification of Oligopeptides Increasing the Effectiveness of Their Interaction with Interleukin-8 in Human Blood Plasma

Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutami...

O. V. Gribovskaya, V. P. Martinovich… in Russian Journal of Bioorganic Chemistry (2020)

Article

The analog of arginine-vasopressin (6-9) fragment, Ac-D-SPRG, exhibits antidepressant action in rats in case of intranasal injection

The antidepressant properties of newly synthesized analog of arginine-vasopressin fragment analog, Ac-D-SPRG, were tested using Porsolt’s swimming test on white rats. It was demonstrated that this substance wh...

A. S. Belyakova, A. A. Sinjushin, O. G. Voskresenskaya… in Neurochemical Journal (2015)

Article

The effect of the glycyl-proline dipeptide on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia

We studied the effects of the glycyl-proline dipeptide (Gly-Pro) at a dose of 3 mg/kg on the contents of neuroactive amino acids, including aspartate, glycine, alanine, taurine, GABA, and glutamate, the activi...

N. Z. Bashun, E. M. Doroshenko, E. F. Raduta, Zh. I. Balash… in Neurochemical Journal (2013)

Article

The synthesis of peptide fragments of high affinity receptor FcɛRI and their binding to allergen-specific immunoglobulins E

Using computer analysis, a minimal sequence of Arg136-Asn137-Trp138-Asp139 that can bind to IgE C3 and C4 fragments was determined for the high-affinity receptor FcɛRI, a key protein of IgE-dependent allergic ...

O. V. Gribovskaya, V. P. Martinovich… in Russian Journal of Bioorganic Chemistry (2012)

Article

Influence of original structural analogue of arginine-vasopressin(6–9), Ac-D-SPRG, on exploratory activity and level of anxiety of white rats

Influence of synthetic analogue of arginine-vasopressin (AVP), Ac-D-SPRG, on exploratory behavior and level of anxiety of white rats was investigated. Ac-D-SPRG was injected nasally in doses of 0.01, 0.1, 1.0,...

A. S. Belyakova, O. G. Voskresenskaya… in Moscow University Biological Sciences Bull… (2012)

Article

IR spectroscopic analysis of the structure of a biospecific sorbent based on a polyethylene matrix

We have used IR spectroscopy to study the structure of a biospecific sorbent based on a polyethylene matrix, modified by radiation grafting of acrylic acid with L-tryptophan methyl ester as the ligand. We show...

E. A. Korolenko, E. V. Korolik, O. N. Tretinnikov… in Journal of Applied Spectroscopy (2010)

Article

Effect of N-terminal tripeptides of bombesin, litorin, and their analogue on body temperature and vasomotor responses

Intranasal administration of bombesin caused hypothermia in rats maintained under cold conditions. N-terminal tripeptide of bombesin exhibits intrinsic vasomotor activity, while intranasal administration of it...

T. G. Emel’yanova, I. V. Sosnovskaya… in Bulletin of Experimental Biology and Medic… (2007)

Article

Synthesis of modified fragments of fibrinogen and their effect on the activity of proteolytic enzymes

New analogues of the Gly-Pro-Arg and Arg-Gly-Asp fragments of fibrinogen were synthesized: Gly-Pro-Arg-Pro (I), Gly-Pro-Arg-Pro-Met-OMe (II), Gly-Pro-Arg-Pro-Phe (III), Gly-Pro-Arg-Pro-Asp (IV), Gly-Pro-Arg-Pro-G...

V. N. Nikandrov, N. S. Pyzhova, V. P. Golubovich… in Russian Journal of Bioorganic Chemistry (2006)

Article

The structure-antiaggregative activity relationship in a series of Arg-Gly-Asp analogues

A series of analogues of Arg-Gly-Asp tripeptide, the common structural element of most of the integrin receptor ligands, possessing different conformational features for the interaction with platelet receptors...

O. V. Mel’nik, V. P. Martinovich… in Russian Journal of Bioorganic Chemistry (2006)

Article

Improvements in the selective perception and training of rats using an original analog of the C-terminal fragment of vasopressin

This report presents studies on the effects of intranasal administration of five doses (0.001, 0.01, 0.1, 1, and 10 μg/kg) of a new analog of arginine-vasopressin fragment AVP_(6–9), i.e., D-MPRG, on the learning ...

N. S. Ponomareva, O. G. Voskresenskaya… in Neuroscience and Behavioral Physiology (2000)

Article

The effects of a novel analog of the C-terminal fragment of vasopressin on the behavior of white rats

The effects of an arginine-vasopressin fragment, Ac-D-MPRG, on the movement activity and orientational-investigative activity of white rats were studied. Peptide was given intranasally at doses of 0.001, 0.01,...

N. S. Ponomareva, O. G. Voskresenskaya… in Neuroscience and Behavioral Physiology (1999)

Article

The effects of analogs of the C-terminal fragment of arginine-vasopressin on the dynamics of development of a conditioned active avoidance response in rats

This paper reports studies of the effects of original analogs of the C-terminal fragment AVP (6–9), D-MPR and D-MPRG, on the development of a conditioned active avoidance response in rats; agents were given in...

O. G. Voskresenskaya, S. A. Titov… in Neuroscience and Behavioral Physiology (1999)

Article

Synthesis of a number of combined analogues of substance P and litorin

With the aim of obtaining new biologically active compounds, we have synthesized nine combined peptides (I)-(IX) consisting of combinations of the C terminal tripeptide litorin and the hydrophobic central frag...

E. N. Galyuk, S. V. Egorova, E. B. Gurina… in Chemistry of Natural Compounds (1992)

Article

Investigation of the structure of L-proline by means of low-temperature IR spectroscopy and conformational analysis

A. A. Ivanov, E. V. Korolik, N. I. Insarova… in Journal of Applied Spectroscopy (1991)

Article

IR spectroscopic study of structure of serum albumin in pathological processes

A. I. Ivanov, A. A. Ivanov, V. P. Golubovich… in Journal of Applied Spectroscopy (1991)

Article

Low-temperature vibrational spectra and molecular structure of L-alanine

A. A. Ivanov, E. V. Korolik, N. I. Insarova… in Journal of Applied Spectroscopy (1990)

Article

Consumption of water and sodium chloride solution by rats after central injection of litorin and after immunization with litorin-bovine serum albumin conjugate

P. A. Ishanov, I. P. Ashmarin, A. I. Esakov… in Bulletin of Experimental Biology and Medic… (1989)