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Article
Method of recording contractions of isolated blood vessels with the aid of a photoresistor
An apparatus for recording the tone and contractions of isolated vessels of various animals is described. The principle of the method consists of recording changes in the volume of an isolated vessel filled wi...
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Article
Role of GABA and glycine in the formation of somato-sympathetic reflexes
The action of strychnine and picrotoxin, synaptic antagonists of glycine and GABA, on the components of somato-sympathetic reflexes evoked by stimulation of cutaneous and intercostal muscular afferents was stu...
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Article
Effect of ultrasound on adhesiveness ofEscherichia coli
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Article
Role of different types of glutamate receptors in spatial memory in rats
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Article
Specific features in the behavior of rats with different genetic stability to stress
The effects of acute and chronic immobilization stress on the behavior of NISAG and outbred rats with different resistance to stress were evaluated. In the acute stress model, NISAG rats did not differ from st...
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Article
Antidepressant Activity of Aspartic Acid Derivatives
Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant acti...
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Article
Efficiency of Potentiated Antibodies to Tumor Necrosis Factor-α (Artrofoon) in the Therapy of Patients with Rheumatoid Arthritis
Antiinflammatory activity of a new preparation Artrofoon (antibodies against tumor necrosis factor-α in ultralow doses) and nonsteroid antiinflammatory drug diclofenac in patients with rheumatoid arthritis was...
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Article
Impaza and Sildenafil: Comparison of Clinical Effectiveness in Patients with Erectile Dysfunction
A blind, placebo-controlled, randomized trial showed clinical effectiveness of the preparation Impaza containing antibodies to endothelial NO synthase in ultralow doses. Impaza surpassed placebo, but was less ...
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Article
Variability of neuronal damage and proportion of activities of NO synthase isoforms during cerebral ischemia/reperfusion in rats
We studied expression of endothelial and neuronal NO synthase isoforms and severity of ischemia/reperfusion-induced damage to neurons in different brain compartments in albino rats. The peculiarities of distri...
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Article
Pharmacodynamics of Kardos Administered as Monotherapy and in Combination with Hypothiazide and Enalapril in Grade I-II Arterial Hypertension
Therapy with kardos produced an antiihypertensve effect in patients with grade I-II arterial hypertension. This antiihypertensve effect was considerably potentiated, when kardos was administered in combination...
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Article
Efficiency and Safety of Long-Term Artrofoon Treatment in Rheumatoid Arthritis
In patients with rheumatoid arthritis, prolongation of artrofoon therapy to 2 years led to maintenance of the positive clinical effect attained after 6-month treatment. Moreover, significant improvement was ob...
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Article
Effect of Combination of Anticytokine Preparations Anaferon and Artrofoon on Immune Inflammation in Rheumatoid Arthritis
Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines ...
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Article
The Use of Ultralow Doses of Antibodies to C-Terminal Fragment of Angiotensin II AT1 Receptor (Kardos) in the Therapy of Arterial Hypertension
Kardos monotherapy allows attaining the target levels of systolic and diastolic blood pressure in patients with high-risk and very-high-risk hypertension. We demonstrated excellent tolerability of the preparat...
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Article
Some aspects of toxicological activity of kardosten after chronic 6-month administration to rats
Chronic treatment of rats with kardosten for 6 months had a positive effect on some ECG values and behavior without disordering the hepatorenal functions. All effects of the drug observed during a course of tr...
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Article
Experimental Study of the Effects of Dietressa, a New Weight-Reducing Drug
The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of dr...
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Article
Antiaggregant Activity of a New Benzimidazole Derivative
Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evalua...
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Article
Experimental Study of the Efficiency of Dietressa Preparation on Body Weight Reduction in Mice Feeding High-Fat Ration
We studied the efficiency of Dietressa on body weight reduction in C57Bl/6 male mice feeding standard high-fat ration (24%). After 5-month daily intragastric administration of Dietressa, body weight gain was t...
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Article
Effects of a New Benzimidazole Derivative on Generative Function of Female Rats
The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 ...
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Article
Effects of Impaza on the Generative Function of Female Rats
The effects of impaza on ovulatory cycles, sexual behavior, and conception processes were studied in female rats. A two-week course of impaza in doses of 3 and 15 ml/kg did not affect alternation of estrous cy...
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Article
Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects
We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation contai...