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Article
Open AccessCombi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets
Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is c...
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Article
Open AccessSurgical management of anterior clinoidal meningiomas: consensus statement on behalf of the EANS skull base section
The optimal management of clinoidal meningiomas (CMs) continues to be debated.
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Article
Petroclival meningiomas: update of current treatment and consensus by the EANS skull base section
The optimal management of petroclival meningiomas (PCMs) continues to be debated along with several controversies that persist.
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Article
Exploration of Gibbs-Laguerre Tessellations for Three-Dimensional Stochastic Modeling
Random tessellations are well suited for probabilistic modeling of three-dimensional (3D) grain microstructures of polycrystalline materials. The present paper is focused on so-called Gibbs-Laguerre tessellati...
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Chapter and Conference Paper
On Statistical Method-Based Information System for Decision Support of Municipalities
The presented contribution is a description of the first output from a project and describes a software solution architecture of performance management tool for public sector economy. The contribution defines ...
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Chapter
Decision Support for Municipality Information System Based on Statistical Methods
The presented contribution is a description of first output from a project and describes a software solution architecture of performance management tool for public sector economy. The contribution defines the ...
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Article
Open AccessBRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene tra...
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Article
Intramedullary ependymoma: long-term outcome after surgery
Overall (OS) and progression-free survival (PFS) of patients undergoing spinal ependymoma resection has been frequently reported. Contrarily, OS and PFS of purely intramedullary ependymomas have not been clear...
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Article
Vertebral artery and osseous anomalies characteristic at the craniocervical junction diagnosed by CT and 3D CT angiography in normal Czech population: analysis of 511 consecutive patients
There are numerous indications for stabilization using instrumentation of the upper cervical spine. This area is comprised of sophisticated anatomy. There is no study describing bony and vascular anomalies of ...
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Article
Open AccessIdentification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia
In the search for genes that define critical steps of relapse in pediatric T-cell acute lymphoblastic leukemia (T-ALL) and can serve as prognostic markers, we performed targeted sequencing of 313 leukemia-rela...
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Article
Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)—a subtype of Hodgkin lymphoma (HL)—is characterized by a low content of tumor cells, the lymphocyte predominant (LP) cells. Transformation into diffuse l...
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Article
Open AccessDe novo assembly and sex-specific transcriptome profiling in the sand fly Phlebotomus perniciosus (Diptera, Phlebotominae), a major Old World vector of Leishmania infantum
The phlebotomine sand fly Phlebotomus perniciosus (Diptera: Psychodidae, Phlebotominae) is a major Old World vector of the protozoan Leishmania infantum, the etiological agent of visceral and cutaneous leishmania...
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Article
Carotid endarterectomy and carotid artery stenting: changing paradigm during 10 years in a high-volume centre
We analysed the results of internal carotid artery (ICA) stenosis treatment at our institution over the last 10 years according to treatment modalities (carotid endarterectomy [CEA] vs carotid artery stenting ...
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Article
Surgery of brainstem cavernous malformations
Cavernomas are vascular hamartomas made up of thin-walled, grossly dilated blood vessels lined with endothelium. Between 4 and 35 % (mean 15 %) of cerebral cavernomas are located in the brainstem making resect...
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Article
Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer
Estrogen effects on mammary epithelial and breast cancer (BC) cells are mediated by the nuclear receptors ERα and ERβ, transcription factors that display functional antagonism with each other, with ERβ acting ...
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Chapter
Traumatic Atlantooccipital Dislocation (AOD)
Atlanto-occipital dislocation (AOD) is a rare, highly unstable ligamentous injury of the craniovertebral junction (CVJ) and, as such, is associated with high mortality and neurological morbidity. It is seen in...
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Chapter
Tumors
At the craniovertebral junction (CVJ) and upper cervical spine (UCS) regions, many types of tumors can be seen;however, the incidence is very low. Using an oncological classification, they can be divided into ...
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Article
In memoriam of Ivan Saxl
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Article
The MRI volumetry of the posterior fossa and its substructures in trigeminal neuralgia: a validated study
Our aim was to determine whether the anatomical configuration of the posterior fossa and its substructures might represent a predisposition factor for the occurrence of clinical neurovascular conflict in trige...
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Chapter
Carotid Endarterectomy
Carotid endarterectomy (CEA) is a means for the secondary prevention of stroke that is caused by embolisation from carotid plaques. CEA is by far the most thoroughly studied surgical procedure as well as one o...
