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Article
Open AccessImproving the TIR3B oncological stratification: try to bridge the gap through a comprehensive presurgical algorithm
Indeterminate cytology still puzzles clinicians, due to its wide range of oncological risks. According to the Italian SIAPEC–IAP classification, TIR3B cytology holds up to 30% of thyroid cancer, which justifie...
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Article
Clinical impact of the new SIAPEC-IAP classification on the indeterminate category of thyroid nodules
The increasing frequency in the diagnosis of thyroid nodules has raised a growing interest in the search for new diagnostic tools to better select patients deserving surgery. In 2014, the major Italian Societi...
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Article
Accuracy and Reproducibility of HER2 Status in Breast Cancer Using Immunohistochemistry: A Quality Control Study in Tuscany Evaluating the Impact of Updated 2013 ASCO/CAP Recommendations
The correct identification of HER2-positive cases is a key point to provide the most appropriate therapy to breast cancer (BC) patients. We aimed at investigating the reproducibility and accuracy of HER2 expre...
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Article
Invasive breast cancer: a significant correlation between histological types and molecular subgroups
The special types of breast cancer seem to have not only distinct morphological features but also distinct biological features.
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Article
International multicenter tool to predict the risk of four or more tumor-positive axillary lymph nodes in breast cancer patients with sentinel node macrometastases
Recently, many centers have omitted routine axillary lymph node dissection (ALND) after metastatic sentinel node biopsy in breast cancer due to a growing body of literature. However, existing guidelines of adj...
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Article
Biological characteristics of interval cancers: a role for biomarkers in the breast cancer screening
In a population-based screening program, a percentage of tumors remain undetected; these tumors comprise a heterogeneous group, and they are more likely to have adverse prognostic features. The aim of this stu...
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Article
Follicular nodules (THY3) of the thyroid: We recommend surgery
Objective: To determine the need of total thyrodectomy for patients with follicular nodules of thyroid. Subjects and methods: From January 2005 through June 2008, 2249 consecutive patients (438 m...
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Article
Open AccessBorderline breast core needle histology: predictive values for malignancy in lesions of uncertain malignant potential (B3)
Breast core needle biopsy (CNB) is an accurate test but may result in borderline histology (lesions of uncertain malignant potential or B3). This is an evaluation of the largest series (to date) of B3 histolog...
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Article
Open AccessQuantification of the effect of mammographic screening on fatal breast cancers: The Florence Programme 1990–96
Breast cancer cases diagnosed in women aged 50–69 since 1990 to 1996 in the City of Florence were partitioned into those who had been invited to screening prior to diagnosis and those who had not. All cases we...
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Article
Mammographic appearance of calcifications as a predictor of intraductal carcinoma histologic subtype
We reviewed 109 consecutive cases of intraductal carcinoma to evaluate the association between histologic subtype (comedo = 35, non-comedo = 71, mixed = 3) and calcification type, as assessed by histology (amo...
