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  1. Article

    Open Access

    Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

    The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is frequently dysregulated in cancers, and gain-of-function (GOF) EZH2 mutations have been identified in non-Hodgkin lymphomas. Small-molecule i...

    V Gibaja, F Shen, J Harari, J Korn, D Ruddy, V Saenz-Vash, H Zhai, T Rejtar… in Oncogene (2016)

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