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Article
Open AccessFeasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) – protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb)
After infection with SARS-CoV-2 a relevant proportion of patients complains about persisting symptoms, a condition termed Post-COVID-19-syndrome (PC19S). So far, possible treatments are under investigation. Am...
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Article
Open AccessConventional versus video-assisted laryngoscopy for perioperative endotracheal intubation (COVALENT) - a randomized, controlled multicenter trial
Data on the routine use of video-assisted laryngoscopy in peri-operative intubations are rather inconsistent and ambiguous, in part due to small populations and non-uniform outcome measures in past trials. Fai...
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Article
Open AccessCombined subthalamic and nucleus basalis of Meynert deep brain stimulation for Parkinson’s disease with dementia (DEMPARK-DBS): protocol of a randomized, sham-controlled trial
Dementia in Parkinson’s disease (PDD) is a common non-motor symptom of advanced disease, associated with pronounced neocortical cholinergic deficits due to neurodegeneration of the nucleus basalis of Meynert (...
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Article
Open AccessQuantification of left ventricular mass by echocardiography compared to cardiac magnet resonance imaging in hemodialysis patients
Left ventricular hypertrophy (LVH), defined by the left ventricular mass index (LVMI), is highly prevalent in hemodialysis patients and a strong independent predictor of cardiovascular events. Compared to card...
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Article
CaboACC: Cabozantinib beim fortgeschrittenen Nebennierenkarzinom nach Versagen der Standardtherapie
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Article
Open AccessPallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)
Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia. Pallidal neurostimulation is a potent alternative, but currently re...
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Article
Open AccessFeasibility and diagnostic accuracy of point-of-care handheld echocardiography in acute ischemic stroke patients – a pilot study
Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to asses...
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Article
Open AccessPerioperative changes in osteopontin and TGFβ1 plasma levels and their prognostic impact for radiotherapy in head and neck cancer
In head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery.
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Article
Open AccessPulmonary wedge resection plus parietal pleurectomy (WRPP) versus parietal pleurectomy (PP) for the treatment of recurrent primary pneumothorax (WOPP trial): study protocol for a randomized controlled trial
For the surgical treatment of recurrent primary spontaneous pneumothoraces (rPSP) different operative therapies are applied to achieve permanent freedom from recurrence.
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Article
iROLL: does 3-D radioguided occult lesion localization improve surgical management in early-stage breast cancer?
To prospectively evaluate the feasibility of 3-D radioguided occult lesion localization (iROLL) and to compare iROLL with wire-guided localization (WGL) in patients with early-stage breast cancer undergoing br...
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Article
Laminar infarcts in clinical routine: a prospective analysis in standard stroke unit patients
The present study aimed to investigate prospectively the frequency of laminar infarcts (LI) within a standard stroke unit population. Laminar infarcts follow neuroanatomical borders rather than the vascular ar...
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Article
Open AccessEnvironmental factors in early childhood are associated with multiple sclerosis: a case-control study
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with increasing incidence mainly in high-income countries. One explanation of this phenomenon may be ...
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Article
Vitamin D receptor haplotypes protect against development of colorectal cancer
We investigated the association of vitamin D receptor polymorphisms and colorectal cancer incidence in a Caucasian population.
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Article
Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers
The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, howev...
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Article
Interaction of CA repeat polymorphism of the endothelial nitric oxide synthase and hyperhomocysteinemia in acute coronary syndromes: evidence of gender-specific differences
We have recently shown that high CA repeat copy numbers (≥ 34 repeats) in intron 13 of the endothelial nitric oxide (eNOS) gene are associated with excess risk of coronary artery disease. Hyperhomocysteinemia ...
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The Application of Statistical Methods of Meta-Analysis for Heterogeneity Modelling in Medicine and Pharmacy, Psychology, Quality Control and Assurance
In the past few years meta-analysis has become increasingly popular in many areas of science such as medicine and pharmacy, psychology and other social sciences. In these areas of application meta-analyses hav...
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Article
Efficient Non-Iterative and Nonparametric Estimation of Heterogeneity Variance for the Standardized Mortality Ratio
In this paper the situation of extra population heterogeneity in the standardized mortality ratio is discussed from the point-of-view of an analysis of variance. First, some simple non-iterative ways are provi...
