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Article
Open AccessUpregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra Pars Compacta, but PD also affec...
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Article
Open AccessMonozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in mono...
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Article
Open AccessAuthor Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
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Article
Open AccessSynaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients
Parkinson’s disease (PD) is a neurodegenerative disease with both genetic and sporadic origins. In this study, we investigated the electrophysiological properties, synaptic activity, and gene expression differ...
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Chapter and Conference Paper
Potato Leaf Disease Detection and Classification Using Deep Learning
Agriculture faces challenges in food crop production and controlling plant diseases, often exacerbated by harmful pesticides. Machine learning and computer vision offer a solution by enabling early disease det...
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Article
Open AccessEarly maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations
Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of genetic variants were reported to be highly...
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Article
Open AccessMaternal death due to ruptured uterus consequent to abruptio placentae: 2 case reports
Abruptio placentae is a complication of pregnancy that can lead to uterine rupture, increasing maternal and fetal mortality, especially when there is a lack of medical outreach in remote areas.
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Article
A robust and efficient image de-fencing approach using conditional generative adversarial networks
Image de-fencing is one of the most important aspects of recreational photography in which the objective is to remove the fence texture present in an image and generate an aesthetically pleasing version of the...
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Article
Open AccessPartial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial i...
