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Article
Navigating the penetrance and phenotypic spectrum of inherited cardiomyopathies
Inherited cardiomyopathies are genetic diseases that can lead to heart failure and sudden cardiac death. These conditions tend to run in families, following an autosomal dominant pattern where first-degree rel...
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Article
Lac-Phe mediates the effects of metformin on food intake and body weight
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metfor...
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Article
Author Correction: Metabolomic epidemiology offers insights into disease aetiology
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Article
Open AccessAuthor Correction: Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations
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Article
Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between metabolites and health-related traits. This emerging and rapidly growing field has improved our understanding of disease aetiol...
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Article
Open AccessWhole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations
Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome seque...
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Article
An atlas of genetic scores to predict multi-omic traits
The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-ef...
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Article
Open AccessProtein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events
There is increasing evidence that HFpEF is a heterogeneous clinical entity and distinct molecular pathways may contribute to pathophysiology. Leveraging unbiased proteomics to identify novel biomarkers, this s...
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Article
Open AccessWhole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Anc...
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Article
Author Correction: Human plasma proteomic profiles indicative of cardiorespiratory fitness
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Article
Human plasma proteomic profiles indicative of cardiorespiratory fitness
Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO2m...
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Article
Open AccessPredictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure
Cardiac involvement in systemic amyloidosis (AL) occurs in ~50% of all AL patients. However once symptomatic heart failure develops, therapeutic options are limited thereby conferring a poor overall prognosis....
