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    Article

    Brain interstitial glycerol correlates with evolving brain injury in paediatric traumatic brain injury

    A better understanding of the complex pathophysiology of traumatic brain injury (TBI) is needed to improve our current therapies. Cerebral microdialysis (CMD) is an advanced method to monitor the brain, but li...

    Nqobile S. Thango, Ursula K. Rohlwink, Lindizwe Dlamini… in Child's Nervous System (2021)

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    Reference Work Entry In depth

    Pediatric Traumatic Brain Injury: Outcomes and Rehabilitation

    The last few decades have witnessed significant advances in the scope of traumatic brain injury (TBI) care and management, which have resulted in better outcomes and decreased rates of death (Coronado et al. 2...

    Leigh E. Schrieff-Elson, Kevin G. F. Thomas… in Textbook of Pediatric Neurosurgery (2020)

  3. Article

    Open Access

    Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

    Tuberculous meningitis (TBM) is the most severe form of TB with high rates of mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebrospinal fluid (CS...

    Ursula K. Rohlwink, Anthony Figaji, Katalin A. Wilkinson… in Nature Communications (2019)

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    Article

    Targeted treatment in severe traumatic brain injury in the age of precision medicine

    In recent years, much progress has been made in our understanding of traumatic brain injury (TBI). Clinical outcomes have progressively improved, but evidence-based guidelines for how we manage patients remain...

    Anthony A. Figaji, A. Graham Fieggen, Ncedile Mankahla… in Child's Nervous System (2017)

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    Living Reference Work Entry In depth

    Pediatric Traumatic Brain Injury: Outcomes and Rehabilitation

    Traumatic brain injury (TBI) remains a leading cause of injury-related death and morbidity in children worldwide. Patients are frequently left with physical, neuropsychological, and behavioral deficits. These ...

    Leigh E. Schrieff-Elson, Kevin G. F. Thomas… in Textbook of Pediatric Neurosurgery

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    Article

    The relationship between basal cisterns on CT and time-linked intracranial pressure in paediatric head injury

    Although intracranial pressure (ICP) monitoring is a cornerstone of care for severe traumatic brain injury (TBI), the indications for ICP monitoring in children are unclear. Often, decisions are based on head ...

    Alison J. Kouvarellis, Ursula K. Rohlwink, Vishesh Sood… in Child's Nervous System (2011)

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    Article

    Methods of monitoring brain oxygenation

    Posttraumatic brain ischemia or hypoxia is a major potential cause of secondary injury that may lead to poor outcome. Avoidance, or amelioration, of this secondary injury depends on early diagnosis and interve...

    Ursula K. Rohlwink, Anthony A. Figaji in Child's Nervous System (2010)