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Article
Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis
To understand prognostic immune cell infiltration signatures in neuroendocrine neoplasms (NENs), particularly pheochromocytoma and paraganglioma (PCPG), we analyzed tumor transcriptomic data from The Cancer Ge...
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Article
Open AccessGlioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb
The invasive nature of GBM combined with the diversity of brain microenvironments creates the potential for a topographic heterogeneity in GBM radioresponse. Investigating the mechanisms responsible for a micr...
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Article
A long noncoding RNA–microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas
In hopes of discovering new markers for metastatic or aggressive phenotypes of pheochromocytomas and paragangliomas (PCPG), we analyzed the noncoding transcriptome from patient gene expression data in The Canc...
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Article
Detection of glioblastoma intratumor heterogeneity in radiosensitivity using patient-derived neurosphere cultures
Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatmen...
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Article
Open AccessEvaluation of the fullerene compound DF-1 as a radiation protector
Fullerene compounds are known to possess antioxidant properties, a common property of chemical radioprotectors. DF-1 is a dendrofullerene nanoparticle with antioxidant properties previously found to be radiopr...
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Article
Open AccessCellMiner: a relational database and query tool for the NCI-60 cancer cell lines
Advances in the high-throughput omic technologies have made it possible to profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. A persistent pr...
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Article
Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)
Standard archival sequence databases have not been designed as tools for genome annotation and are far from being optimal for this purpose. We used the database of Clusters of Orthologous Groups of proteins (C...
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Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus
The IGF-1 receptor (IGF-1R) is a member of the tyrosine kinase class of cell surface receptors which become autophosphorylated on tyrosyl residues upon ligand binding (Czech, 1989). It has striking homology to...
