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Article
Proteotype profiling unmasks a viral signalling network essential for poxvirus assembly and transcriptional competence
To orchestrate context-dependent signalling programmes, poxviruses encode two dual-specificity enzymes, the F10 kinase and the H1 phosphatase. These signalling mediators are essential for poxvirus production, ...
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Article
Open AccessGenome-wide transcription start site map** of Bradyrhizobium japonicum grown free-living or in symbiosis – a rich resource to identify new transcripts, proteins and to study gene regulation
Differential RNA-sequencing (dRNA-seq) is indispensable for determination of primary transcriptomes. However, using dRNA-seq data to map transcriptional start sites (TSSs) and promoters genome-wide is a bioinf...
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Article
Open AccessExplosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms
Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not...
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Article
A critical cross-validation of high throughput structural binding prediction methods for pMHC
T-cells recognize antigens via their T-cell receptors. The major histocompatibility complex (MHC) binds antigens in a specific way, transports them to the surface and presents the peptides to the TCR. Many in ...
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Chapter and Conference Paper
Interactive Molecular Dynamics Simulations on the Grid
The impressive growth of life sciences in the last couple of years forced computer scientists to deal with scientific areas like biochemistry, biophysics or medicine. Studies in these research areas are often ...
