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Harnessing Alternative Substrates to Probe TET Family Enzymes
TET family enzymes normally oxidize 5-methylcytosine (5mC) in DNA, and play critical roles in sha** the epigenome. Despite their importance, assessing TET activity can be difficult, particularly given the ch...
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Article
Open AccessModular affinity-labeling of the cytosine demethylation base elements in DNA
5-methylcytosine is the most studied DNA epigenetic modification, having been linked to diverse biological processes and disease states. The elucidation of cytosine demethylation has drawn added attention the ...
