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  1. No Access

    Article

    Effects of Copper on Root Morphology, Cations Accumulation, and Oxidative Stress of Grapevine Seedlings

    In the present study, a hydroponic experiment was conducted to investigate the oxidative stress and the copper (Cu) accumulation in grapevines exposed to three Cu levels (0, 5, and 15 µM) for 1, 2, and 3 days....

    Kai-Wei Juang, Yu-Ching Lo, Tzu-Hsuan Chen in Bulletin of Environmental Contamination an… (2019)

  2. Article

    Open Access

    Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

    Recent studies have revealed that cardiac glycosides, such as digitalis and digoxin, have anticancer activity and may serve as lead compounds for the development of cancer treatments. The poor prognosis of hep...

    Min-Wu Chao, Tzu-Hsuan Chen, Han-Li Huang, Yu-Wei Chang in Scientific Reports (2017)

  3. No Access

    Article

    Thermal stability and folding kinetics analysis of disordered protein, securin

    Lacking a stable tertiary structure, intrinsically disordered proteins (IDPs) possess particular functions in cell regulation, signaling, and controlling pathways. The study of their unique structural features...

    Hsueh-Liang Chu, Tzu-Hsuan Chen in Journal of Thermal Analysis and Calorimetry (2014)

  4. No Access

    Article

    Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells

    Denbinobin is a phenanthraquinone derivative present in the stems of Ephemerantha lonchophylla. We showed that denbinobin induces apoptosis in human colorectal cancer cells (HCT-116) in a concentration-dependent ...

    Tzu-Hsuan Chen, Shiow-Lin Pan, Jih-Hwa Guh in Naunyn-Schmiedeberg's Archives of Pharmaco… (2008)