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Article
A genome scan for genes underlying adult body size differences between Central African hunter-gatherers and farmers
The evolutionary and biological bases of the Central African “pygmy” phenotype, a characteristic of rainforest hunter-gatherers defined by reduced body size compared with neighboring farmers, remain largely un...
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Article
Open AccessWeighted likelihood inference of genomic autozygosity patterns in dense genotype data
Genomic regions of autozygosity (ROA) arise when an individual is homozygous for haplotypes inherited identical-by-descent from ancestors shared by both parents. Over the past decade, they have gained importan...
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Article
Open AccessSequence differences at orthologous microsatellites inflate estimates of human-chimpanzee differentiation
Microsatellites---contiguous arrays of 2–6 base-pair motifs---have formed the cornerstone of population-genetic studies for over two decades. Their genotype data typically takes the form of PCR fragment length...
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Article
Open AccessSequence determinants of human microsatellite variability
Microsatellite loci are frequently used in genomic studies of DNA sequence repeats and in population studies of genetic variability. To investigate the effect of sequence properties of microsatellites on their...
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Article
Open AccessPrevalence of common disease-associated variants in Asian Indians
Asian Indians display a high prevalence of diseases linked to changes in diet and environment that have arisen as their lifestyle has become more westernized. Using 1200 genome-wide polymorphisms in 432 indivi...
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Article
A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3
Amelogenesis imperfecta (AI) is a collective term used to describe phenotypically diverse forms of defective tooth enamel development. AI has been reported to exhibit a variety of inheritance patterns, and sev...
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Article
Open AccessIdentification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires
The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the...
