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  1. Article

    Open Access

    Automated acquisition of explainable knowledge from unannotated histopathology images

    Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show th...

    Yoichiro Yamamoto, Toyonori Tsuzuki, Jun Akatsuka, Masao Ueki in Nature Communications (2019)

  2. Article

    Open Access

    Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

    Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). Howeve...

    Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto in Scientific Reports (2022)

  3. Article

    Open Access

    Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy

    The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate c...

    Koichiro Kurokawa, Yasutaka Yamada, Shinichi Sakamoto in Scientific Reports (2024)