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Article
OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway
We analyzed the interaction between a bacterial cell wall protein and dendritic cells (DCs). Outer membrane protein A from Klebsiella pneumoniae (kpOmpA) specifically bound to professional antigen presenting cell...
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Article
Open AccessNutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway
The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical substrate for protein glycosylation. Despite its bi...
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Chapter
TLR3 Is a Death Receptor Target in Cancer Therapy
TLR3 is a pattern-recognition receptor specialized in detecting extracellular double-stranded RNAs (dsRNAs) that sign the presence of virus. Accordingly, TLR3 triggers a Type I-IFN dominated inflammatory respo...
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Article
Open AccessRelease of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis
Toll-like receptor 3 (TLR3) mediates innate immune responses by sensing viral dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by immunohistochemistry revealed that TLR3 is frequentl...
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Article
A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model
Modeling paraneoplastic neurological diseases to understand the immune mechanisms leading to neuronal death is a major challenge given the rarity and terminal access of patients’ autopsies. Here, we present a ...
