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Article
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) n...
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Article
Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum
Voltage-gated Na+ channel β-subunits are multifunctional molecules that modulate Na+ channel activity and regulate cell adhesion, migration and neurite outgrowth. β-subunits including β4 are known to be highly co...
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Article
Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying “behavioral despair” in mice
CS mice exhibit several distinct phenotypes of circadian behavioral rhythms and sleep properties. Because many mental illnesses are associated with abnormalities in the circadian rhythms and sleep pattern, we ...
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Article
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests
Shizufumi Ebihara and colleagues report the identification of Usp46 as a quantitative trait gene underlying mouse behavior in the tail suspension and forced swimming tests, which are widely used for assessing dep...
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Article
Roles of μ-Opioid Receptors in GABAergic Synaptic Transmission in the Striosome and Matrix Compartments of the Striatum
The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input–output connections, and time of neurogenesis. Since it is thought t...
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Chapter
Actions of Dopamine on the Rat Striatal Cholinergic Interneurons
Based on the clinical observations it was classically assumed in the 1960s that there is a mutual antagonism between dopamine (DA) and acetylcholine (ACh) within the striatum (Barbeau, 1962; Lehmann and Langer, 1...
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Chapter
Dopaminergic Regulation of Synaptic Plasticity of Striatal Cholinergic Interneurons
Striatal cholinergic interneurons have been implicated in associative learning.1 In behaving monkeys, the tonically active cholinergic interneurons (TANs) acquire dopamine (DA)-dependent conditioned responses dur...
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Chapter
Substance P Excites Large Aspiny Neurons of the Rat Neostriatum
Substance P (SP) is widely distributed in the mammalian central nervous system, where it is believed to play important roles as a neurotransmitter/neuromodulator. In the striatum, it has been reported that SP-...
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Article
Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons
High-voltage-activated (HVA) Ca-channel currents in chick sensory neurons were characterized by dihydropyridine compounds (DHPs) and ω-conotoxin GVIA (ωCTX) using patch-clamp methods. In single-channel recordi...
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Article
Modulation of Ca-channel current by an adenosine analog mediated by a GTP-binding protein in chick sensory neurons
Inhibitory modulation of the high-voltage-activated (HVA) Ca-channel current by 2-chloroadenosine (2CA) was studied in chick sensory neurons using the whole-cell clamp method. 2CA reduced the ωCTX-sensitive HV...